Epithelial surfaces line the body and provide a crucial interface between the body and the external environment. Tissue-resident epithelial γδ T cells represent a major T cell population in the epithelial tissues and are ideally positioned to carry out barrier surveillance and aid in tissue homeostasis and repair. In this Review, we focus on the intraepithelial γδ T cell compartment of the two largest epithelial tissues in the body — namely, the epidermis and the intestine — and provide a comprehensive overview of the crucial contributions of intraepithelial γδ T cells to tissue integrity and repair, host homeostasis and protection in the context of the symbiotic relationship with the microbiome and during pathogen clearance. Finally, we describe epithelium-specific butyrophilin-like molecules and briefly review their emerging role in selectively shaping and regulating epidermal and intestinal γδ T cell repertoires.

中文翻译：

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稳态中的γδT细胞和上皮屏障组织的宿主防御

上皮表面排布在身体内，并在身体和外部环境之间提供了至关重要的界面。驻留在组织中的上皮γδT细胞代表上皮组织中的主要T细胞群体，并且位置理想，可以进行屏障监测并帮助组织稳态和修复。在本综述中，我们着重研究了人体中两个最大的上皮组织即表皮和肠的上皮内γδT细胞区室，并全面概述了上皮内γ的关键作用。δT细胞在与微生物组的共生关系和病原体清除过程中可以组织完整性和修复，宿主稳态和保护作用。最后，我们描述了上皮特异性的嗜酪蛋白样分子，并简要回顾了它们在选择性塑造和调节表皮和肠道γδT细胞库中的新兴作用。