Phaseic acid (PA) has long been considered an inactive oxidation catabolite of the essential plant hormone abscisic acid (ABA). However, a recent study disclosed that PA actually acts as an ABA receptor agonist and is capable of prolonging ABA effects in vivo. Here, we report a simple, enantioselective synthesis of (−)-phaseic acid. Key transformations of our strategy include a facile hydrozirconation reaction and a critical, Mn(III)-catalyzed allylic oxidation.

中文翻译：

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（-）-相酸的对映选择性合成†

长期以来，相酸（PA）被认为是必需植物激素脱落酸（ABA）的无活性氧化分解代谢物。但是，最近的一项研究表明，PA实际上起着ABA受体激动剂的作用，并且能够在体内延长ABA的作用。在这里，我们报告了一种简单的对映体合成（-）-相酸的方法。我们策略的关键转变包括轻松的加氢锆反应和关键的Mn（III）催化的烯丙基氧化。