Asymmetric synthesis of 3-aminodihydrocoumarins via the chiral guanidine catalyzed cascade reaction of azlactones†,Organic Chemistry Frontiers

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Asymmetric synthesis of 3-aminodihydrocoumarins via the chiral guanidine catalyzed cascade reaction of azlactones†
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1039/c7qo00768j
Sai Ruan _{1,

2,

3,

4,

5} , Xiaobin Lin _{1,

2,

3,

4,

5} , Lihua Xie _{1,

2,

3,

4,

5} , Lili Lin _{1,

2,

3,

4,

5} , Xiaoming Feng _{1,

2,

3,

4,

5} , Xiaohua Liu _{1,

2,

3,

4,

5}

Affiliation

A highly efficient bifunctional guanidine catalyst was developed for the asymmetric cascade reaction between 2-nitrovinylphenols and azlactones. A wide variety of 3-aminodihydrocoumarin derivatives could be obtained in high yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (>19 : 1 dr).

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