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Characterizing Frontal Lobe Seizure Semiology in Children Ann. Neurol. (IF 11.2) Pub Date : 2024-04-16 Thijs van Dalen, Jessica F Kirkham, Aswin Chari, Felice D'Arco, Friederike Moeller, Christin Eltze, J Helen Cross, Martin M Tisdall, Rachel C Thornton
ObjectiveThe objective was to analyze seizure semiology in pediatric frontal lobe epilepsy patients, considering age, to localize the seizure onset zone for surgical resection in focal epilepsy.MethodsFifty patients were identified retrospectively, who achieved seizure freedom after frontal lobe resective surgery at Great Ormond Street Hospital. Video‐electroencephalography recordings of preoperative
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Divergent Associations of Slow‐Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid‐Beta Ann. Neurol. (IF 11.2) Pub Date : 2024-04-16 Yevgenia Rosenblum, Mariana Pereira, Oliver Stange, Frederik D. Weber, Leonore Bovy, Sofia Tzioridou, Elisa Lancini, David A. Neville, Nadja Klein, Timo de Wolff, Mandy Stritzke, Iris Kersten, Manfred Uhr, Jurgen A. H. R. Claassen, Axel Steiger, Marcel M. Verbeek, Martin Dresler
ObjectiveRecent evidence shows that during slow‐wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid‐beta protein. Poor sleep or elevated cortisol levels can worsen amyloid‐beta clearance, potentially leading to the formation of amyloid plaques, a neuropathological hallmark of Alzheimer disease. Here, we explored how nocturnal neural and endocrine activity
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Quantitative Foot Muscle Magnetic Resonance Imaging Reliably Measures Disease Progression in Children and Adolescents with Charcot–Marie–Tooth Disease Type 1A Ann. Neurol. (IF 11.2) Pub Date : 2024-04-13 Carolynne M. Doherty, Paige Howard, Luke F. O'Donnell, Riccardo Zuccarino, Stephen Wastling, Evelin Milev, Tina Banks, Sachit Shah, Nick Zafeiropoulos, Katherine J. Stephens, Anna Sarkozy, Tiffany Grider, Shawna M. E. Feely, Adnan Manzur, Rosemary R. Shy, Mariola Skorupinska, Menelaos Pipis, Emma Nicolaisen, Amy McDowell, Nuran Dilek, Alexander M. Rossor, Matilde Laura, Christopher Clark, Francesco
Quantitative muscle fat fraction (FF) responsiveness is lower in younger Charcot–Marie–Tooth disease type 1A (CMT1A) patients with lower baseline calf‐level FF. We investigated the practicality, validity, and responsiveness of foot‐level FF in this cohort involving 22 CMT1A patients and 14 controls. The mean baseline foot‐level FF was 25.9 ± 20.3% in CMT1A patients, and the 365‐day FF (n = 15) increased
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Current State of Evidence for Neuroimaging Paradigms in Management of Acute Ischemic Stroke Ann. Neurol. (IF 11.2) Pub Date : 2024-04-12 Amrou Sarraj, Deep K Pujara, Bruce CV Campbell
Stroke is the chief differential diagnosis in patient presenting to the emergency room with abrupt onset focal neurological deficits. Neuroimaging, including non‐contrast computed tomography (CT), magnetic resonance imaging (MRI), vascular and perfusion imaging, is a cornerstone in the diagnosis and treatment decision‐making. This review examines the current state of evidence behind the different imaging
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Diagnostic Utility of MOG Antibody Testing in Cerebrospinal Fluid Ann. Neurol. (IF 11.2) Pub Date : 2024-04-09 Vyanka Redenbaugh, James P. Fryer, Laura Cacciaguerra, John J. Chen, Tammy M. Greenwood, Michael Gilligan, Smathorn Thakolwiboon, Masoud Majed, Nicholas H Chia, Andrew McKeon, John R. Mills, A. Sebastian Lopez Chiriboga, Jan‐Mendelt Tillema, Binxia Yang, Yahya Abdulrahman, Kai Guo, Nisa Vorasoot, Cristina Valencia Sanchez, Deena A. Tajfirouz, Michel Toledano, Anastasia Zekeridou, Divyanshu Dubey, Grace
ObjectiveThe aim of this study was to assess the diagnostic utility of cerebrospinal fluid (CSF) myelin oligodendrocyte glycoprotein antibodies (MOG‐IgG) testing.MethodsWe retrospectively identified patients for CSF MOG‐IgG testing from January 1, 1996, to May 1, 2023, at Mayo Clinic and other medical centers that sent CSF MOG‐IgG for testing including: controls, 282; serum MOG‐IgG positive MOG antibody‐associated
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Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy Ann. Neurol. (IF 11.2) Pub Date : 2024-04-05 Indira Garcia-Cordero, Chloe Anastassiadis, Abeer Khoja, Alonso Morales-Rivero, Simrika Thapa, Anna Vasilevskaya, Carly Davenport, Vishaal Sumra, Blas Couto, Namita Multani, Foad Taghdiri, Cassandra Anor, Karen Misquitta, Lawren Vandevrede, Hilary Heuer, David Tang-Wai, Bradford Dickerson, Alexander Pantelyat, Irene Litvan, Bradley Boeve, Julio C. Rojas, Peter Ljubenkov, Edward Huey, Susan Fox, Gabor
To evaluate the effect of Alzheimer's disease (AD) -related biomarker change on clinical features, brain atrophy and functional connectivity of patients with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP).
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Blood‐Based Proteomics for Adult‐Onset Focal Dystonias Ann. Neurol. (IF 11.2) Pub Date : 2024-04-05 Jigyasha Timsina, Ashok Dinasarapu, Gamze Kilic‐Berkmen, John Budde, Yun Ju Sung, Adam M. Klein, Carlos Cruchaga, H. A. Jinnah
ObjectivesThe adult‐onset focal dystonias are characterized by over‐active muscles leading to abnormal movements. For most cases, the etiology and pathogenesis remain unknown. In the current study, unbiased proteomics methods were used to identify potential changes in blood plasma proteins.MethodsA large‐scale unbiased proteomics screen was used to compare proteins (N = 6,345) in blood plasma of normal
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Sex Differences in Amyotrophic Lateral Sclerosis Survival and Progression: A Multidimensional Analysis Ann. Neurol. (IF 11.2) Pub Date : 2024-04-03 Maurizio Grassano, Cristina Moglia, Francesca Palumbo, Emanuele Koumantakis, Paolo Cugnasco, Stefano Callegaro, Antonio Canosa, Umberto Manera, Rosario Vasta, Filippo De Mattei, Enrico Matteoni, Giuseppe Fuda, Paolina Salamone, Giulia Marchese, Federico Casale, Fabiola De Marchi, Letizia Mazzini, Gabriele Mora, Andrea Calvo, Adriano Chiò
ObjectiveTo investigate sex‐related differences in amyotrophic lateral sclerosis (ALS) prognosis and their contributing factors.MethodsOur primary cohort was the Piemonte and Aosta Register for ALS (PARALS); the Pooled Resource Open‐Access ALS Clinical Trials (PRO‐ACT) and the Answer ALS databases were used for validation. Survival analyses were conducted accounting for age and onset site. The roles
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Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis Ann. Neurol. (IF 11.2) Pub Date : 2024-04-03 Massimiliano Calabrese, Paolo Preziosa, Antonio Scalfari, Elisa Colato, Damiano Marastoni, Martina Absinta, Marco Battaglini, Nicola De Stefano, Massimiliano Di Filippo, Simon Hametner, Owain W. Howell, Matilde Inglese, Hans Lassmann, Roland Martin, Richard Nicholas, Richard Reynolds, Maria A. Rocca, Agnese Tamanti, Marco Vercellino, Luisa Maria Villar, Massimo Filippi, Roberta Magliozzi
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability, which proceeds relentlessly and independently of clinical and radiological relapses (PIRA). The complex system of pathological events driving “chronic” worsening is likely linked with
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Bilateral Hearing Loss Caused by Inferior Collicular Infarction Ann. Neurol. (IF 11.2) Pub Date : 2024-04-03 Lingjia Xu, Yang Zhou, Feng Zhou, Guoping Fu
Potential Conflicts of Interest Nothing to report.
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High Frequency of Cognitive and Behavioral Impairment in Amyotrophic Lateral Sclerosis Patients with SOD1 Pathogenic Variants Ann. Neurol. (IF 11.2) Pub Date : 2024-04-03 Andrea Calvo, Cristina Moglia, Antonio Canosa, Umberto Manera, Rosario Vasta, Maurizio Grassano, Margherita Daviddi, Filippo De Mattei, Enrico Matteoni, Salvatore Gallone, Maura Brunetti, Luca Sbaiz, Sara Cabras, Laura Peotta, Francesca Palumbo, Barbara Iazzolino, Gabriele Mora, Adriano Chiò
ObjectiveWhile the cognitive‐behavioral characteristics of amyotrophic lateral sclerosis (ALS) patients carrying C9orf72 pathological repeat expansion have been extensively studied, our understanding of those carrying SOD1 variants is mostly based on case reports. The aim of this paper is to extensively explore the cognitive‐behavioral characteristics of a cohort of ALS patients carrying pathogenetic
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Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-04-02 Paulina Gonzalez‐Latapi, Bernabe Bustos, Siyuan Dong, Steven Lubbe, Tanya Simuni, Dimitri Krainc
ObjectiveTo characterize DNA methylation (DNAm) differences between sporadic Parkinson's disease (PD) and healthy control (HC) individuals enrolled in the Parkinson's Progression Markers Initiative (PPMI).MethodsUsing whole blood, we characterized longitudinal differences in DNAm between sporadic PD patients (n = 196) and HCs (n = 86) enrolled in PPMI. RNA sequencing (RNAseq) was used to conduct gene
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Reply to “An Apple a Day Will Not Keep the (Parkinson's Disease) Doctor at Bay!” Ann. Neurol. (IF 11.2) Pub Date : 2024-04-01 Erik Post, Deborah A. Hall, Bastiaan R. Bloem
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Towards a Global View of Parkinson's Disease Genetics Ann. Neurol. (IF 11.2) Pub Date : 2024-04-01 Marzieh Khani, Catalina Cerquera‐Cleves, Mariam Kekenadze, Peter Wild Crea, Andrew B. Singleton, Sara Bandres‐Ciga
Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non‐European populations has revealed novel population‐specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is
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Compensated Hypogonadism Identified in Males with Cluster Headache: A Prospective Case‐Controlled Study Ann. Neurol. (IF 11.2) Pub Date : 2024-04-01 Anja S. Petersen, David M. Kristensen, Connar S. J. Westgate, Thomas Folkmann‐Hansen, Nunu Lund, Mads Barloese, Marie‐Louise K. Søborg, Agneta Snoer, Trine H. Johannsen, Hanne Frederiksen, Anders Juul, Rigmor H. Jensen
ObjectiveAndrogens have been hypothesized to be involved in the pathophysiology of cluster headache due to the male predominance, but whether androgens are altered in patients with cluster headache remains unclear.MethodsWe performed a prospective, case‐controlled study in adult males with cluster headache. Sera were measured for hormones including testosterone, luteinizing hormone (LH), and sex hormone‐binding
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An Apple a Day Will Not Keep the (Parkinson Disease) Doctor at Bay! Ann. Neurol. (IF 11.2) Pub Date : 2024-03-30 Alexandra Boogers, Alfonso Fasano, Anthony Lang
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HLA Associations of Intrathecal IgG Production against Specific Viruses in Multiple Sclerosis Ann. Neurol. (IF 11.2) Pub Date : 2024-03-29 Stephan Neidhart, Benjamin Vlad, Marc Hilty, Klara Asplund Högelin, Mario Ziegler, Ernesto Berenjeno‐Correa, Ina Reichen, Pernilla Stridh, Ivan Jelcic, Mohsen Khademi, Ingrid Kockum, Mireia Sospedra, Faiez Al Nimer, Roland Martin, Ilijas Jelcic
ObjectiveSpecific human leucocyte antigen (HLA) alleles are not only associated with higher risk to develop multiple sclerosis (MS) and other autoimmune diseases, but also with the severity of various viral and bacterial infections. Here, we analyzed the most specific biomarker for MS, that is, the polyspecific intrathecal IgG antibody production against measles, rubella, and varicella zoster virus
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Retraction: 5‐Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease Ann. Neurol. (IF 11.2) Pub Date : 2024-03-28
Retraction: Jin Chu, Phillip F. Giannopoulos, Carolina Ceballos‐Diaz, Todd E. Golde, Domenico Pratico (2012), 5‐Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease. Ann Neurol., 72: 442–454. https://doi.org/10.1002/ana.23642The above article, published online on 09 May 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted
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α‐Synuclein Pathology in PRKN‐Linked Parkinson's Disease: New Insights from a Blood‐Based Seed Amplification Assay Ann. Neurol. (IF 11.2) Pub Date : 2024-03-28 Annika Kluge, Max Borsche, Linn Streubel‐Gallasch, Tuğçe Gül, Susen Schaake, Alexander Balck, Jannik Prasuhn, Philip Campbell, Huw R. Morris, Anthony H. Schapira, Katja Lohmann, Norbert Brüggemann, Aleksandar Rakovic, Philip Seibler, A. Nazlı Başak, Daniela Berg, Christine Klein
Pathogenic variants in PRKN cause early‐onset Parkinson's disease (PD), while the role of alpha‐synuclein in PRKN‐PD remains uncertain. One study performed a blood‐based alpha‐synuclein seed amplification assay (SAA) in PRKN‐PD, not detecting seed amplification in 17 PRKN‐PD patients. By applying a methodologically different SAA focusing on neuron‐derived extracellular vesicles, we demonstrated alpha‐synuclein
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Real‐World Healthcare Cost Savings and Reduced Relapse Rate with Off‐Label Rituximab versus Disease‐Modifying Treatments Approved for Relapsing–Remitting Multiple Sclerosis: A Nationwide Cost‐Effectiveness Study Ann. Neurol. (IF 11.2) Pub Date : 2024-03-26 Peter Alping, Martin Neovius, Fredrik Piehl, Thomas Frisell
ObjectiveAlthough off‐label use of rituximab is a common alternative to disease‐modifying therapies (DMTs) approved for multiple sclerosis (MS) in several countries, the impact of this on treatment cost‐effectiveness is not well known.MethodsWe evaluated the relative cost‐effectiveness of rituximab and MS‐approved DMTs in a register‐based cohort study of Swedish residents with relapsing–remitting MS
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Pro‐Hemorrhagic Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Associated with NOTCH3 p.R75P Mutation with Low Vascular NOTCH3 Aggregation Property Ann. Neurol. (IF 11.2) Pub Date : 2024-03-23 Hiroyuki Ishiyama, Hyunjin Kim, Satoshi Saito, Soichi Takeda, Misa Takegami, Yumi Yamamoto, Soichiro Abe, Shinsaku Nakazawa, Tomotaka Tanaka, Kazuo Washida, Yoshiaki Morita, Seung‐Taek Oh, Hee‐Jae Jung, Jay Chol Choi, Yuriko Nakaoku, Jin Nakahara, Masatoshi Koga, Kazunori Toyoda, Kisaki Amemiya, Yoshihiko Ikeda, Kinta Hatakeyama, Ikuko Mizuta, Toshiki Mizuno, Kwang‐Kuk Kim, Masafumi Ihara
ObjectivesIntracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy are more common in East Asian populations than in people of white European ancestry. We hypothesized that the ethnic difference is explained by the East Asian‐specific NOTCH3 p.R75P mutation.MethodsThis retrospective observational study
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Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases Ann. Neurol. (IF 11.2) Pub Date : 2024-03-22 Tomomi Kanazawa, Wakiro Sato, Ben J.E. Raveney, Daiki Takewaki, Atsuko Kimura, Hiromi Yamaguchi, Yuma Yokoi, Reiko Saika, Yuji Takahashi, Tsuneo Fujita, Shinji Saiki, Akira Tamaoka, Shinji Oki, Takashi Yamamura
Eomesodermin‐expressing (Eomes+) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th
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Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data Ann. Neurol. (IF 11.2) Pub Date : 2024-03-20 Alwan Iktimal, Dennis D. Spencer, Rafeed Alkawadri
Using 6‐minute free‐running intracranial‐electroencephalogram (icEEG) during sleep, an optimized multilayer perceptron (MLP) neural network accurately maps the sensorimotor cortex (SM) and identifies the anterior lip of the central sulcus (CS) in intractable epilepsy patients. We calculated 6 performance metrics to evaluate the MLP's efficacy: accuracy, area under the curve (AUC), recall, precision
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Reply to “Letter on Spasticity Predicts Motor Recovery in Motor Complete Spinal Cord Injury” Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Sina Sangari, Bing Chen, Sara Hobbs, Amanda Olson, Alan Anschel, Ki Kim, David Chen, Allison Kessler, Allen W. Heinemann, Martin Oudega, Brian K. Kwon, Steven Kirshblum, James D. Guest, Monica A. Perez
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Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Victor A Del Bene, Roy C. Martin, Sarah A. Brinkerhoff, Joseph W. Olson, Matthew J. Nelson, Dario Marotta, Christopher L. Gonzalez, Kelly A. Mills, Vidyulata Kamath, Gary Cutter, Chris P. Hurt, Melissa Wade, Frank G. Robinson, J. Nicole Bentley, Barton L. Guthrie, Robert T. Knight, Harrison C. Walker
ObjectiveThe aim of this study was to investigate the cognitive effects of unilateral directional versus ring subthalamic nucleus deep brain stimulation (STN DBS) in patients with advanced Parkinson's disease.MethodsWe examined 31 participants who underwent unilateral STN DBS (left n = 17; right n = 14) as part of an National Institutes of Health (NIH)‐sponsored randomized, double‐blind, crossover
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Mitochondrial Dysfunction of Peripheral Platelets as a Predictive Biomarker for Postoperative Delirium in Elderly Patients Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Yan Yang, Wei Zhang, Yue Liu, Xin Liu, Jun Xie, Rui Xu, Yulin Huang, Jing Hao, Yu'e Sun, Xiaoping Gu, Zhengliang Ma
ObjectiveTo determine the association between the preoperative Bioenergetic Health Index (BHI) of platelets and the occurrence of postoperative delirium (POD) in elderly patients.MethodsElderly patients scheduled for major abdominal surgery under general anesthesia were included. The presence of POD was assessed within the 3 days after surgery. Seahorse XF analysis and transmission electron microscopy
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Beyond the Final Heartbeat: Neurological Perspectives on Normothermic Regional Perfusion for Organ Donation after Circulatory Death Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Matthew P. Kirschen, Ariane Lewis, Michael A. Rubin, Panayiotis N. Varelas, David M. Greer
Normothermic regional perfusion (NRP) has recently been used to augment organ donation after circulatory death (DCD) to improve the quantity and quality of transplantable organs. In DCD‐NRP, after withdrawal of life‐sustaining therapies and cardiopulmonary arrest, patients are cannulated onto extracorporeal membrane oxygenation to reestablish blood flow to targeted organs including the heart. During
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Neuromuscular Ultrasound in Cervical Nerve Root Avulsion Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Nicholas J Miller, James B Meiling, James B Caress, Michael S Cartwright
A 22-year-old man was injured in a high-speed motor vehicle collision, sustaining multiple limb fractures and pneumothoraxes. Immediately following the accident, he had difficulty moving his right upper limb. A brachial plexus injury was suspected. He was referred for electrodiagnostic studies (EDX) 3 months later, without imaging studies available for review. At the time of EDX, he described minimal
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Furthering Female Faculty: An American Neurological Association/Association of University Professors of Neurology Perspective Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 L. John Greenfield, Shilpi Mittal, Sima I. Patel, Christa O'Hana S. Nobleza, Deborah Bradshaw
Potential Conflicts of Interest Nothing to report.
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Accumulation of Lewy‐Related Pathology Starts in Middle Age: The Tampere Sudden Death Study Ann. Neurol. (IF 11.2) Pub Date : 2024-03-19 Eloise H Kok, Anders Paetau, Mika Martiskainen, Leo‐Pekka Lyytikäinen, Terho Lehtimäki, Pekka Karhunen, Liisa Myllykangas
When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha‐synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy‐related
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Is High‐Frequency Activity at Seizure Onset Inhibitory? A Stereoelectroencephalographic Study of Motor Cortex Seizures Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Hussam Shaker, Jian Li, Masako Kobayashi, Olesya Grinenko, Juan Bulacio, Richard M. Leahy, Patrick Chauvel
ObjectiveIn the era of stereoelectroencephalography (SEEG), many studies have been devoted to understanding the role of interictal high‐frequency oscillations. High‐frequency activity (HFA) at seizure onset has been identified as a marker of epileptogenic zone. We address the physiological significance of ictal HFAs and their relation to clinical semiology.MethodsWe retrospectively identified patients
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Blood Pressure after Successful Endovascular Therapy: A Systematic Review and Meta‐Analysis of Randomized Control Trials Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Khaled Gharaibeh, Nameer Aladamat, Adam T. Mierzwa, Rahul Rao, Hisham Alhajala, Sami Al Kasab, Mohammad Anadani, Richard Burgess, Syed Zaidi, Mouhammad Jumaa
ObjectiveThere are limited data evaluating the optimum blood pressure (BP) goal post mechanical thrombectomy (MT) and its effect on outcomes of patients with large vessel occlusions (LVO). The objective of this study was to compare the efficacy and safety of intensive versus conventional BP control after reperfusion with MT via a systematic review and meta‐analysis of randomized controlled trials (RCTs)
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Cognitive Impairment Is Related to Glymphatic System Dysfunction in Pediatric Multiple Sclerosis Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Monica Margoni, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca
ObjectiveThe aim of this study was to investigate whether, compared to pediatric healthy controls (HCs), the glymphatic system is impaired in pediatric multiple sclerosis (MS) patients according to their cognitive status, and to assess its association with clinical disability and MRI measures of brain structural damage.MethodsSixty‐five pediatric MS patients (females = 62%; median age = 15.5 [interquartile
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Trigeminal Trophic Syndrome from Lateral Medullary Stroke Ann. Neurol. (IF 11.2) Pub Date : 2024-03-14 Gareth Zigui Lim, Jiekai Tan
Potential Conflicts of Interest Nothing to report.
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Letter on Spasticity Predicts Motor Recovery in Motor Complete Spinal Cord Injury Ann. Neurol. (IF 11.2) Pub Date : 2024-03-12 Jing Chen
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Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort Ann. Neurol. (IF 11.2) Pub Date : 2024-03-11 Eleni Palpatzis, Muge Akinci, Pablo Aguilar-Dominguez, Marina Garcia-Prat, Kaj Blennow, Henrik Zetterberg, Margherita Carboni, Gwendlyn Kollmorgen, Norbert Wild, Karine Fauria, Carles Falcon, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, Eider M. Arenaza-Urquijo
Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies, neuroinflammation, and gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk of AD
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Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy Ann. Neurol. (IF 11.2) Pub Date : 2024-03-11 Dario Arnaldi, Pietro Mattioli, Stefano Raffa, Matteo Pardini, Federico Massa, Alex Iranzo, Andres Perissinotti, Aida Niñerola-Baizán, Carles Gaig, Monica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Agostino Chiaravalloti, Karel Šonka, Petr Dušek, David Zogala, Jiri Trnka, Bradley F. Boeve, Toji Miyagawa, Val J. Lowe, Tomoyuki Miyamoto, Masayuki
To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB).
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High‐Frequency Spinal Stimulation Suppresses Microglial Kaiso‐P2X7 Receptor Axis‐Induced Inflammation to Alleviate Neuropathic Pain in Rats Ann. Neurol. (IF 11.2) Pub Date : 2024-03-07 Jing Yu, Stanley Wong, Zhinan Lin, Zhiming Shan, Chaoyang Fan, Zhengyuan Xia, Martin Cheung, Xiaowei Zhu, Jessica Aijia Liu, Chi Wai Cheung
ObjectiveNeuropathic pain poses a persistent challenge in clinical management. Neuromodulation has emerged as a last‐resort therapy. Conventional spinal cord stimulation (Con SCS) often causes abnormal sensations and provides short analgesia, whereas high‐frequency spinal cord stimulation (HF SCS) is a newer therapy that effectively alleviates pain without paresthesia. However, the modes of action
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Fostering Academia‐Industry Partnerships to Facilitate Therapeutic Discoveries in Neurology: The Role of ANA as a Catalyst Ann. Neurol. (IF 11.2) Pub Date : 2024-03-04 M. Elizabeth Ross, Dimitri Krainc, Ming Guo, M. Maral Mouradian, Rajiv R. Ratan
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In Memoriam: Henry F. McFarland (1940–2024) Ann. Neurol. (IF 11.2) Pub Date : 2024-02-29 Daniel S. Reich
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Epstein–Barr Virus Strongly Associates With Pediatric Multiple Sclerosis, But Not Myelin Oligodendrocyte Glycoprotein-Antibody-Associated Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-02-27 Giulia Fadda, Carmen Yea, Julia O'Mahony, Patrick Waters, E. Ann Yeh, Ruth Ann Marrie, Douglas Arnold, Amit Bar-Or, Brenda Banwell
Reported rates of Epstein–Barr virus (EBV) seropositivity in children meeting multiple sclerosis (MS) diagnostic criteria are considerably lower than those reported in adult-onset MS, putting in question a requisite role for EBV in MS development. As prior work preceded recognition of myelin oligodendrocyte glycoprotein-associated disease (MOGAD), we assessed viral serologies in 251 children with incident
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Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions Ann. Neurol. (IF 11.2) Pub Date : 2024-02-27 Stacey A. Sakowski, Emily J. Koubek, Kevin S. Chen, Stephen A. Goutman, Eva L. Feldman
Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview
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Associations of 24‐Hour Rest‐Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-02-26 Maxime Van Egroo, Eus J.W. van Someren, Lea T. Grinberg, David A. Bennett, Heidi I.L. Jacobs
ObjectiveWhile studies suggested that locus coeruleus (LC) neurodegeneration contributes to sleep–wake dysregulation in Alzheimer's disease (AD), the association between LC integrity and circadian rest‐activity patterns remains unknown. Here, we investigated the relationships between 24‐hour rest‐activity rhythms, cognitive trajectories, and autopsy‐derived LC integrity in older adults with and without
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Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study Ann. Neurol. (IF 11.2) Pub Date : 2024-02-26 Aline Thomas, Calen P. Ryan, Avshalom Caspi, Zhonghua Liu, Terrie E. Moffitt, Karen Sugden, Jiayi Zhou, Daniel W. Belsky, Yian Gu
ObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years‐old, free of dementia and having dietary, epigenetic
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Increased Cortical Thickness in Alzheimer's Disease Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Tony X. Phan, Sheena Baratono, William Drew, Aaron M. Tetreault, Michael D. Fox, R. Ryan Darby,
Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, and mechanisms associated with increased cortical thickness in AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated to atrophied regions
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Ictal Central Apnea Is Predictive of Mesial Temporal Seizure Onset: An Intracranial Investigation Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Nuria Lacuey, Blanca Talavera, Oman Magana‐Tellez, Oscar Mancera‐Páez, Norma Hupp, Xi Luo, Johnson P. Hampson, Jaison Hampson, M. R. Sandhya Rani, Manuela Ochoa‐Urrea, Omar A. Alamoudi, Stephen Melius, Sandipan Pati, Jay Gavvala, Nitin Tandon, John C. Mosher, Samden D. Lhatoo
ObjectiveIctal central apnea (ICA) is a semiological sign of focal epilepsy, associated with temporal and frontal lobe seizures. In this study, using qualitative and quantitative approaches, we aimed to assess the localizational value of ICA. We also aimed to compare ICA clinical utility in relation to other seizure semiological features of focal epilepsy.MethodsWe analyzed seizures in patients with
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Effect of Statin Therapy on Cardiovascular Outcome in Stroke Patients with Low Baseline Low‐Density Lipoprotein Cholesterol Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Yong Soo Kim, Han‐Gil Jeong, Jun Young Chang, Jun Yup Kim, Beom Joon Kim, Hee‐Joon Bae, Moon‐Ku Han
ObjectivesTo investigate whether post‐stroke statin therapy reduces subsequent major vascular events in statin‐naïve patients with pretreatment low‐density lipoprotein cholesterol (LDL‐C) below the recommended target (≤70 mg/dL for atherosclerotic stroke and ≤100 mg/dL for non‐atherosclerotic stroke) at stroke onset.MethodsPatients from an ongoing stroke registry who had an ischemic stroke between
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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501 Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Yaqing Shu, Renliang Huang, Qihui Li, Yi Lu, Junping Yin, Huilu Li, Zhike Lan, Xiujun Zheng, Jinlong Ye, Youming Long, Zhanhang Wang, Li Xiao, Qiaomiao Zhou, Xu Liu, Ying Fu, Hao Chen, Juanjuan Chen, Yanxia Zhou, Juan Zhou, Liting Zhang, Jing Zhou, Ying Jiang, Fuhua Peng, Zhengqi Lu, Frank Petersen, Wei Qiu, Xinhua Yu
We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32–3.06, p = 0.00072, padj. = 0.046) and HLA‐DBP1*0501 (OR = 0.51, 95% CI = 0.36–0.71, p = 0.000048
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Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset Ann. Neurol. (IF 11.2) Pub Date : 2024-02-24 Yan Li, Daniel Yen, Rachel D. Hendrix, Brian A. Gordon, Sibonginkhosi Dlamini, Nicolas R. Barthélemy, Andrew J. Aschenbrenner, Rachel L. Henson, Elizabeth M. Herries, Katherine Volluz, Kristopher Kirmess, Stephanie Eastwood, Matthew Meyer, Maren Heller, Lea Jarrett, Eric McDade, David M. Holtzman, Tammie L.S. Benzinger, John C. Morris, Randall J. Bateman, Chengjie Xiong, Suzanne E. Schindler
ObjectiveA clock relating amyloid positron emission tomography (PET) to time was used to estimate the timing of biomarker changes in sporadic Alzheimer disease (AD).MethodsResearch participants were included who underwent cerebrospinal fluid (CSF) collection within 2 years of amyloid PET. The ages at amyloid onset and AD symptom onset were estimated for each individual. The timing of change for plasma
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Efficacy of Endovascular Thrombectomy in Acute Basilar Artery Occlusion with Low PC-ASPECTS: A Nationwide Prospective Registry-Based Study Ann. Neurol. (IF 11.2) Pub Date : 2024-02-21 Jun Young Chang, Ji Sung Lee, Wook-Joo Kim, Jee Hyun Kwon, Beom Joon Kim, Joon-Tae Kim, Jun Lee, Jae Kwan Cha, Dae-Hyun Kim, Yong-Jin Cho, Keun-Sik Hong, Soo Joo Lee, Jong-Moo Park, Kyusik Kang, Byung-Chul Lee, Kyung-Ho Yu, Sang-Hwa Lee, Chulho Kim, Kwang-Yeol Park, Dong-Eog Kim, Kyungbok Lee, Tai Hwan Park, Jay Chol Choi, Dong-Ick Shin, Sung-Il Sohn, Hee-Joon Bae, Moon-Ku Han
We evaluated the efficacy of endovascular thrombectomy (EVT) on the functional outcome of patients with acute basilar artery occlusion and low posterior circulation acute stroke prognosis early computed tomography score (PC-ASPECTS).
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Cortical Thickness Patterns of Cognitive Impairment Phenotypes in Drug‐Resistant Temporal Lobe Epilepsy Ann. Neurol. (IF 11.2) Pub Date : 2024-02-23 Gadi Miron, Paul Manuel Müller, Louisa Hohmann, Frank Oltmanns, Martin Holtkamp, Christian Meisel, Claudia Chien
ObjectiveIn temporal lobe epilepsy (TLE), a taxonomy classifying patients into 3 cognitive phenotypes has been adopted: minimally, focally, or multidomain cognitively impaired (CI). We examined gray matter (GM) thickness patterns of cognitive phenotypes in drug‐resistant TLE and assessed potential use for predicting postsurgical cognitive outcomes.MethodsTLE patients undergoing presurgical evaluation
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Seizure Cycles under Pharmacotherapy Ann. Neurol. (IF 11.2) Pub Date : 2024-02-21 Cecilia Friedrichs‐Maeder, Timothée Proix, Thomas K. Tcheng, Tara Skarpaas, Vikram R. Rao, Maxime O. Baud
ObjectiveThis study was undertaken to determine the effects of antiseizure medications (ASMs) on multidien (multiday) cycles of interictal epileptiform activity (IEA) and seizures and evaluate their potential clinical significance.MethodsWe retrospectively analyzed up to 10 years of data from 88 of the 256 total adults with pharmacoresistant focal epilepsy who participated in the clinical trials of
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Associations of Serum Insulin and Related Measures With Neuropathology and Cognition in Older Persons With and Without Diabetes Ann. Neurol. (IF 11.2) Pub Date : 2024-02-21 Zoe Arvanitakis, Ana W. Capuano, Han Tong, Rupal I. Mehta, Frederick Anokye‐Danso, David A. Bennett, Steven E. Arnold, Rexford S. Ahima
ObjectiveTo examine associations of serum insulin and related measures with neuropathology and cognition in older persons.MethodsWe studied 192 older persons (96 with diabetes and 96 without, matched by sex and balanced by age‐at‐death, education, and postmortem interval) from a community‐based, clinical‐pathologic study of aging, with annual evaluations including neuropsychological testing (summarized
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Levodopa Impairs the Energy Metabolism of the Basal Ganglia In Vivo Ann. Neurol. (IF 11.2) Pub Date : 2024-02-17 Jannik Prasuhn, Tanja Schiefen, Theresia Güber, Julia Henkel, Jan Uter, Julia Steinhardt, Britta Wilms, Norbert Brüggemann
One proposed mechanism of disease progression in Parkinson's disease includes the interplay of endogenous dopamine toxicity and mitochondrial dysfunction. However, the in-vivo effects of exogenous dopamine administration on cerebral bioenergetics are unknown.
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White and Gray Matter Changes are Associated With Neurocognitive Decline in HIV Infection Ann. Neurol. (IF 11.2) Pub Date : 2024-02-16 Alice Chien, Tianxia Wu, Chuen-Yen Lau, Darshan Pandya, Amanda Wiebold, Brian Agan, Joseph Snow, Bryan Smith, Avindra Nath, Govind Nair
To investigate the relationship between neurocognitive deficits and structural changes on brain magnetic resonance imaging in people living with HIV (PLWH) with good virological control on combination antiretroviral therapy, compared with socioeconomically matched control participants recruited from the same communities.
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Intensive Blood Pressure Treatment and Subclinical Brain Infarcts: A Secondary Analysis of SPRINT (Systolic Pressure Intervention Trial) Ann. Neurol. (IF 11.2) Pub Date : 2024-02-16 Kyle C. Kern, Ilya M. Nasrallah, R. Nick Bryan, Jeff Williamson, David M. Reboussin, Nicholas M. Pajewski, Clinton B. Wright
Subclinical brain infarcts (SBI) increase the risk for stroke and dementia, but whether they should be considered equivalent to symptomatic stroke when determining blood pressure targets remains unclear. We tested whether intensive systolic blood pressure (SBP) treatment reduced the risk of new SBI or stroke and determined the association between SBI and cognitive impairment.