Annual Review of Virology ( IF 11.3 ) Pub Date : 2016-10-14 00:00:00 , DOI: 10.1146/annurev-virology-100114-054908 Paul F. Lambert 1
Genetically engineered mice (GEMs) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. This review provides an overview of seminal discoveries made through the use of GEM models for human DNA tumor viruses. Emphasis is placed on the discoveries made in the study of human papillomaviruses, Merkel cell carcinoma–associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma–associated herpesvirus, because GEMs have contributed extensively to our understanding of how these DNA tumor viruses directly contribute to human cancers.
中文翻译：
肿瘤病毒作用的转基因小鼠模型
基因工程小鼠（GEM）为各种人类肿瘤病毒的致癌特性提供了宝贵的见解，这些病毒在病因学上总计占所有人类癌症的15％以上。这篇综述概述了通过使用GEM模型对人类DNA肿瘤病毒进行的开创性发现。重点放在人类乳头瘤病毒，默克尔细胞癌相关的多瘤病毒，爱泼斯坦-巴尔病毒和卡波西氏肉瘤相关的疱疹病毒的研究中，因为GEM广泛地帮助我们了解了这些DNA肿瘤病毒如何直接导致人类癌症。
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