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Nuclear Exodus: Herpesviruses Lead the Way
Annual Review of Virology ( IF 11.3 ) Pub Date : 2016-10-14 00:00:00 , DOI: 10.1146/annurev-virology-110615-042215
Janna M. Bigalke 1 , Ekaterina E. Heldwein 1
Affiliation  

Most DNA viruses replicate in the nucleus and exit it either by passing through the nuclear pores or by rupturing the nuclear envelope. Unusually, herpesviruses have evolved a complex mechanism of nuclear escape whereby nascent capsids bud at the inner nuclear membrane to form perinuclear virions that subsequently fuse with the outer nuclear membrane, releasing capsids into the cytosol. Although this general scheme is accepted in the field, the players and their roles are still debated. Recent studies illuminated critical mechanistic features of this enigmatic process and uncovered surprising parallels with a novel cellular nuclear export process. This review summarizes our current understanding of nuclear egress in herpesviruses, examines the experimental evidence and models, and outlines outstanding questions with the goal of stimulating new research in this area.

中文翻译:


核外逃:疱疹病毒带路

大多数DNA病毒在细胞核中复制并通过核孔或破坏核被膜而退出细胞核。异常地,疱疹病毒进化出复杂的核逃逸机制,由此新生的衣壳在内核膜上萌芽形成核周病毒体,随后与外核膜融合,从而将衣壳释放到胞质溶胶中。尽管这种通用方案在现场已被接受,但球员及其角色仍在争论中。最近的研究阐明了这种神秘过程的关键机制特征,并发现了与新型细胞核输出过程相似的令人惊讶的相似之处。这篇评论总结了我们目前对疱疹病毒核出口的了解,研究了实验证据和模型,

更新日期:2016-10-14
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