Zika virus (ZIKV) is rapidly spreading throughout the Americas and is associated with significant fetal complications, most notably microcephaly. Treatment with polyclonal antibodies for pregnant women at risk of ZIKV-related complications could be a safe alternative to vaccination. We found that large quantities of human polyclonal antibodies could be rapidly produced in transchromosomal bovines (TcB) and successfully used to protect mice from lethal infection. Additionally, antibody treatment eliminated ZIKV induced tissue damage in immunologically privileged sites such as the brain and testes and protected against testicular atrophy. These data indicate that rapid development and deployment of human polyclonal antibodies could be a viable countermeasure against ZIKV.

寨卡病毒（ZIKV）在整个美洲迅速传播，并与严重的胎儿并发症（尤其是小头畸形）有关。对于患有ZIKV相关并发症风险的孕妇，用多克隆抗体治疗可能是接种疫苗的安全替代方法。我们发现大量人多克隆抗体可以在转染色体牛（TcB）中快速产生，并成功用于保护小鼠免受致命感染。此外，抗体治疗消除了ZIKV诱导的在免疫学上优先的位点（如大脑和睾丸）中的组织损伤，并防止了睾丸萎缩。这些数据表明，人类多克隆抗体的快速开发和部署可能是针对ZIKV的可行对策。