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Biologically active quinoline and quinazoline alkaloids part I
Medicinal Research Reviews ( IF 13.3 ) Pub Date : 2017-09-13 , DOI: 10.1002/med.21466
Xiao-Fei Shang,Susan L. Morris-Natschke,Ying-Qian Liu,Xiao Guo,Xiao-Shan Xu,Masuo Goto,Jun-Cai Li,Guan-Zhou Yang,Kuo-Hsiung Lee

Quinoline and quinazoline alkaloids, two important classes of N‐based heterocyclic compounds, have attracted tremendous attention from researchers worldwide since the 19th century. Over the past 200 years, many compounds from these two classes were isolated from natural sources, and most of them and their modified analogs possess significant bioactivities. Quinine and camptothecin are two of the most famous and important quinoline alkaloids, and their discoveries opened new areas in antimalarial and anticancer drug development, respectively. In this review, we survey the literature on bioactive alkaloids from these two classes and highlight research achievements prior to the year 2008 (Part I). Over 200 molecules with a broad range of bioactivities, including antitumor, antimalarial, antibacterial and antifungal, antiparasitic and insecticidal, antiviral, antiplatelet, anti‐inflammatory, herbicidal, antioxidant and other activities, were reviewed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

中文翻译:

生物活性喹啉和喹唑啉生物碱第一部分

喹啉和喹唑啉生物碱是两类重要的基杂环化合物,自19世纪以来引起了全世界研究人员的极大关注。在过去的 200 年里,这两类化合物中的许多化合物都是从天然来源中分离出来的,其中大多数及其修饰的类似物都具有显着的生物活性。奎宁和喜树碱是两种最著名和最重要的喹啉生物碱,它们的发现分别开辟了抗疟疾和抗癌药物开发的新领域。在这篇综述中,我们调查了这两类生物活性生物碱的文献,并重点介绍了 2008 年之前的研究成果(第一部分)。审查了 200 多个具有广泛生物活性的分子,包括抗肿瘤、抗疟疾、抗菌和抗真菌、抗寄生虫和杀虫、抗病毒、抗血小板、抗炎、除草、抗氧化和其他活性。这项调查应该为从原始天然存在的喹啉和喹唑啉生物碱中发现新的更好的药物提供新的线索或可能性。
更新日期:2017-09-13
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