当前位置: X-MOL 学术J. Antibiot. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2017-Sep-13 , DOI: 10.1038/ja.2017.103
Toshihiko Nogawa , Naoki Kato , Takeshi Shimizu , Akiko Okano , Yushi Futamura , Shunji Takahashi , Hiroyuki Osada

Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus, Pyrenochaetopsis sp. RK10-F058, by screening for structurally unique metabolites using LC/MS analysis. Their structures were determined on the basis of NMR and mass spectrometric measurements. The absolute structures were confirmed by a combination of chemical methods including chemical degradation, a modified Mosher's method and Marfey's method, and comparison of the experimental electronic CD (ECD) spectrum with calculated one. Both compounds had a cyclopentanone-fused decaline skeleton and an N-methylated amino acid moiety derived from a serine. They showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.The Journal of Antibiotics advance online publication, 13 September 2017; doi:10.1038/ja.2017.103.

中文翻译:

Wakodecalines A和B,从真菌Pyrenochaetopsis sp。分离的新的十氢化萘代谢物。RK10-F058。

从真菌Pyrenochaetopsis sp。分离出了两种新的十氢化萘代谢物,wakodecalines A和B。RK10-F058,通过使用LC / MS分析筛选结构独特的代谢产物。根据NMR和质谱测量确定它们的结构。绝对结构通过化学方法(包括化学降解),改进的Mosher方法和Marfey方法以及实验电子CD(ECD)光谱与计算得出的光谱相结合来确认。两种化合物均具有环戊酮稠合的十氢化萘骨架和衍生自丝氨酸的N-甲基化氨基酸部分。他们显示出对恶性疟原虫3D7菌株的中等抗疟活性。《抗生素杂志》在线提前出版,2017年9月13日; doi:10.1038 / ja.2017.103。
更新日期:2017-09-13
down
wechat
bug