LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression.

中文翻译：

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当LMO1遇上MYCN时，神经母细胞瘤是转移性的。

LMO1是一个高风险的神经母细胞瘤易感基因，但尚不清楚LMO1与MYCN在神经母细胞瘤肿瘤发生中如何协同作用。在本期《癌细胞》中，Zhu等人。开发一种新型的斑马鱼模型，阐明了LMO1和MYCN协同启动神经母细胞瘤并促进转移性疾病进展的机制。