Natural products are significant therapeutic agents and valuable drug leads. This is likely owing to their three-dimensional structural complexity, which enables them to form complex interactions with biological targets. Enzymes from natural product biosynthetic pathways show great potential to generate natural product-like compounds and libraries. Many challenges still remain in biosynthesis, such as how to rationally synthesize small molecules with novel structures and how to generate maximum chemical diversity.

中文翻译：

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产生多样性的生物合成的三个原理

天然产物是重要的治疗剂和有价值的药物线索。这可能是由于它们的三维结构复杂性，使它们能够与生物靶标形成复杂的相互作用。来自天然产物生物合成途径的酶显示出产生天然产物样化合物和文库的巨大潜力。生物合成仍然面临许多挑战，例如如何合理合成具有新颖结构的小分子以及如何产生最大的化学多样性。