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Role of Biocatalysis in Sustainable Chemistry
Chemical Reviews ( IF 62.1 ) Pub Date : 2017-09-06 00:00:00 , DOI: 10.1021/acs.chemrev.7b00203
Roger A. Sheldon 1, 2 , John M. Woodley 3
Affiliation  

Based on the principles and metrics of green chemistry and sustainable development, biocatalysis is both a green and sustainable technology. This is largely a result of the spectacular advances in molecular biology and biotechnology achieved in the past two decades. Protein engineering has enabled the optimization of existing enzymes and the invention of entirely new biocatalytic reactions that were previously unknown in Nature. It is now eminently feasible to develop enzymatic transformations to fit predefined parameters, resulting in processes that are truly sustainable by design. This approach has successfully been applied, for example, in the industrial synthesis of active pharmaceutical ingredients. In addition to the use of protein engineering, other aspects of biocatalysis engineering, such as substrate, medium, and reactor engineering, can be utilized to improve the efficiency and cost-effectiveness and, hence, the sustainability of biocatalytic reactions. Furthermore, immobilization of an enzyme can improve its stability and enable its reuse multiple times, resulting in better performance and commercial viability. Consequently, biocatalysis is being widely applied in the production of pharmaceuticals and some commodity chemicals. Moreover, its broader application will be further stimulated in the future by the emerging biobased economy.

中文翻译:

生物催化在可持续化学中的作用

基于绿色化学和可持续发展的原则和指标,生物催化既是绿色又是可持续的技术。这在很大程度上是过去二十年来分子生物学和生物技术取得了令人瞩目的进步的结果。蛋白质工程技术可以优化现有酶,并发明了自然界中以前未知的全新生物催化反应。现在,开发适合预定参数的酶促转化方法绝对可行,从而可以真正实现可持续的设计流程。该方法已经成功地应用于例如活性药物成分的工业合成中。除了使用蛋白质工程技术外,生物催化工程技术的其他方面(例如底物,培养基和反应器工程技术)可以用来提高效率和成本效益,从而提高生物催化反应的可持续性。此外,固定化酶可以提高其稳定性并使其能够多次重复使用,从而获得更好的性能和商业可行性。因此,生物催化被广泛应用于药物和某些商品化学品的生产中。此外,新兴的生物基经济将在未来进一步刺激其更广泛的应用。生物催化已被广泛应用于药物和某些日用化学品的生产中。此外,新兴的生物基经济将在未来进一步刺激其更广泛的应用。生物催化已被广泛应用于药物和某些日用化学品的生产中。此外,新兴的生物基经济将在未来进一步刺激其更广泛的应用。
更新日期:2017-09-06
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