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Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2017-01-06 , DOI: 10.1016/j.plipres.2017.01.001
Erik Messamore , Daniel M. Almeida , Ronald J. Jandacek , Robert K. McNamara

A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Cross-national and cross-sectional evidence suggests that greater habitual intake of n-3 PUFA is associated with reduced risk for developing mood symptoms. Meta-analyses provide strong evidence that patients with mood disorders exhibit low blood n-3 PUFA levels which are associated with increased risk for the initial development of mood symptoms in response to inflammation. While the etiology of this n-3 PUFA deficit may be multifactorial, n-3 PUFA supplementation is sufficient to correct this deficit and may also have antidepressant effects. Rodent studies suggest that n-3 PUFA deficiency during perinatal development can recapitulate key neuropathological, neurochemical, and behavioral features associated with mood disorders. Clinical neuroimaging studies suggest that low n-3 PUFA biostatus is associated with abnormalities in cortical structure and function also observed in mood disorders. Collectively, these findings implicate dietary n-3 PUFA insufficiency, particularly during development, in the pathophysiology of mood dysregulation, and support implementation of routine screening for and treatment of n-3 PUFA deficiency in patients with mood disorders.



中文翻译:

多不饱和脂肪酸和复发性情绪障碍:现象学,机理和临床应用

有证据表明,包括重度抑郁症(MDD)在内的复发性情绪障碍的病理生理和病因包括膳食中缺乏ω-3多不饱和脂肪酸(n -3 PUFA),包括二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)。 )和躁郁症。跨国和横断面证据表明,习惯性摄入n -3 PUFA的量增加与出现情绪症状的风险降低有关。荟萃分析提供了有力的证据,表明情绪障碍患者的血液n -3 PUFA水平较低,这与因炎症引起的情绪症状初始发展的风险增加有关。虽然这n的病因-3 PUFA缺陷可能是多因素的,n -3 PUFA补充剂足以纠正该缺陷,并且也可能具有抗抑郁作用。啮齿动物研究表明,围产期发育期间n -3 PUFA缺乏可概括与情绪障碍相关的关键神经病理学,神经化学和行为特征。临床神经影像研究表明,低n -3 PUFA生物状态与在情绪障碍中也观察到的皮质结构和功能异常有关。总的来说,这些发现暗示了饮食中n -3 PUFA的不足,尤其是在发育过程中,在情绪失调的病理生理中,并支持常规筛查和治疗n-3情绪障碍患者的PUFA缺乏症。

更新日期:2017-01-06
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