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Sphingolipids and glycerophospholipids – The “ying and yang” of lipotoxicity in metabolic diseases
Progress in Lipid Research ( IF 13.6 ) Pub Date : 2017-01-16 , DOI: 10.1016/j.plipres.2017.01.002
S Rodriguez-Cuenca 1 , V Pellegrinelli 1 , M Campbell 1 , M Oresic 2 , A Vidal-Puig 3
Affiliation  

Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic crosstalk between sphingolipids and glycerophospholipids, whose dysregulation contributes to lipotoxicity induced metabolic stress. The initial evidence for this crosstalk originates from simulated models designed to investigate the biophysical properties of sphingolipids in plasma membrane representations. In this review, we reinterpret some of the original findings and conceptualise them as a sort of “ying/yang” interaction model of opposed/complementary forces, which is consistent with the current knowledge of lipid homeostasis and pathophysiology. We also propose that the dysregulation of the balance between sphingolipids and glycerophospholipids results in a lipotoxic insult relevant in the pathophysiology of common metabolic diseases, typically characterised by their increased ceramide/sphingosine pools.



中文翻译:

鞘脂和甘油磷脂——代谢疾病中脂毒性的“阴阳”

一般的鞘脂,特别是神经酰胺,通过改变信号传导和代谢途径来促进病理生理机制。在这里,我们提出了鞘脂和甘油磷脂之间双向稳态串扰的现有证据,其失调会导致脂毒性诱导的代谢应激。这种串扰的最初证据来源于模拟模型,该模型旨在研究质膜表征中鞘脂的生物物理特性。在这篇综述中,我们重新解释了一些最初的发现,并将它们概念化为一种相反/互补力的“/”相互作用模型,这与当前脂质稳态和病理生理学的知识是一致的。我们还提出,鞘脂和甘油磷脂之间的平衡失调会导致与常见代谢疾病的病理生理学相关的脂毒性损伤,其典型特征是神经酰胺/鞘氨醇库增加。

更新日期:2017-01-16
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