Lipid metabolism is a complex physiological process that is involved in nutrient adjustment, hormone regulation, and homeostasis. An unhealthy lifestyle and chronic nutrient overload can cause lipid metabolism disorders, which may lead to serious lipid-related diseases, including obesity, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes mellitus (T2DM). Therefore, tools for preventing dysfunctional lipid metabolism are urgently needed. The transcription factor forkhead box protein O1 (FOXO1) is involved in lipid metabolism and plays a critical role in the development of lipid-related diseases. In this review, we provide a global perspective on the role of FOXO1 in lipid metabolism and lipid-related diseases. The information included here may be useful for the design of future studies and advancing investigations of FOXO1 as a therapeutic target.

脂质代谢是一个复杂的生理过程，涉及营养调节，激素调节和体内平衡。不健康的生活方式和长期的营养过剩会导致脂质代谢紊乱，从而可能导致严重的脂质相关疾病，包括肥胖，非酒精性脂肪肝疾病（NAFLD）和2型糖尿病（T2DM）。因此，迫切需要用于预防脂质代谢异常的工具。转录因子叉头盒蛋白O1（FOXO1）参与脂质代谢，并在脂质相关疾病的发展中发挥关键作用。在这篇综述中，我们提供了FOXO1在脂质代谢和脂质相关疾病中的作用的全球视角。