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Encapsulation systems for the delivery of hydrophilic nutraceuticals: Food application
Biotechnology Advances ( IF 16.0 ) Pub Date : 2017-04-01 , DOI: 10.1016/j.biotechadv.2017.03.012
N.P. Aditya , Yadira Gonzalez Espinosa , Ian T. Norton

Increased health risk associated with the sedentary life style is forcing the food manufacturers to look for food products with specific or general health benefits e.g. beverages enriched with nutraceuticals like catechin, curcumin rutin. Compounds like polyphenols, flavonoids, vitamins are the good choice of bioactive compounds that can be used to fortify the food products to enhance their functionality. However due to low stability and bioavailability of these bioactives (both hydrophobic and hydrophilic) within the heterogeneous food microstructure and in the Gastro Intestinal Tract (GIT), it becomes extremely difficult to pass on the real health benefits to the consumers.

Recent developments in the application of nano-delivery systems for food product development is proving to be a game changer which has raised the expectations of the researchers, food manufacturers and consumers regarding possibility of enhancing the functionality of bioactives within the fortified food products. In this direction, nano/micro delivery systems using lipids, surfactants and other materials (carbohydrates, polymers, complexes, protein) have been fabricated to stabilize and enhance the biological activity of the bioactive compounds.

In the present review, current status of the various delivery systems that are used for the delivery of hydrophilic bioactives and future prospects for using other delivery systems that have been not completely explored for the delivery of hydrophilic bioactives e.g. niosomes; bilosomes, cubosomes are discussed.



中文翻译:

用于输送亲水性保健食品的封装系统:食品应用

与久坐不动的生活方式有关的健康风险增加,迫使食品制造商寻找具有特定或一般健康益处的食品,例如富含儿茶素,姜黄素芦丁等营养食品的饮料。诸如多酚,类黄酮,维生素之类的化合物是生物活性化合物的理想选择,可用于强化食品以增强其功能。然而,由于这些生物活性物质(疏水性和亲水性)在异质食品微观结构内和胃肠道(GIT)中的稳定性和生物利用度较低,因此很难将真正的健康益处传递给消费者。

纳米递送系统在食品开发中的应用的最新发展被证明是一种改变游戏规则的方法,它提高了研究人员,食品制造商和消费者对增强食品中生物活性剂功能性的期望。在这个方向上,已经制造出使用脂质,表面活性剂和其他材料(碳水化合物,聚合物,复合物,蛋白质)的纳米/微递送系统,以稳定和增强生物活性化合物的生物活性。

在本综述中,用于递送亲水性生物活性物质的各种递送系统的当前状态以及使用尚未完全探索用于递送亲水性生物活性物质的其他递送系统的未来前景,例如脂质体;讨论了二元体,立方体。

更新日期:2017-04-01
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