The principal event of aberrant gene expression occurs in numerous disorders and syndromes, including heart failure. LncRNAs may constitute powerful treatment targets because they intensively interact with their genetic environment, as they are important regulators of genetic networks. Recent advances on the functional roles of lncRNAs in cardiac hypertrophy are expected to usher improved therapeutic strategies.

中文翻译：

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Linc-荷兰国际集团非编码基因组心功能：打肥大

基因表达异常的主要事件发生在许多疾病和综合征中，包括心力衰竭。由于LncRNA是遗传网络的重要调节剂，因此它们与它们的遗传环境密切相互作用，因此可能构成强大的治疗靶标。预期lncRNA在心脏肥大中的功能作用的最新进展将引入改进的治疗策略。