Aneuploidy is ubiquitous in cancer and plays a pivotal, early role in tumor evolution. It must therefore be avoided, and two recent papers highlight the roles of p53, senescence, and the immune system in preventing the outgrowth of aneuploid clones in tissue culture. These mechanisms are likely to synergize to maintain diploid cell populations.

中文翻译：

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非整倍性警察检测到染色体失衡引发免疫镇压！

非整倍体在癌症中无处不在，并且在肿瘤发展中起着关键的早期作用。因此必须避免这种情况，最近的两篇论文强调了p53，衰老和免疫系统在防止组织培养中非整倍体克隆的生长中的作用。这些机制可能协同作用以维持二倍体细胞群体。