A recent analysis of paralog deletion in yeast has shown that functional compensation and dependency occur equally. While theory predicts that compensation produces robustness, the authors hypothesized that stabilization of one paralogous protein through interaction with its copy could explain dependency. Here, we provide alternative explanations, such as selection for increased protein dosage and hypofunctionalization.

中文翻译：

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基因重复：鲁棒性还是脆弱性？

最近对酵母中的旁系同源物缺失的分析表明，功能补偿和依赖性同样发生。尽管理论上预测补偿会产生鲁棒性，但作者假设通过一种旁系蛋白与其拷贝的相互作用来稳定其稳定性可以解释依赖性。在这里，我们提供了替代性的解释，例如增加蛋白质剂量和功能不足的选择。