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Natural-Product Antibiotics: Cues for Modulating Bacterial Biofilm Formation
Trends in Microbiology ( IF 15.9 ) Pub Date : 2017-07-05 , DOI: 10.1016/j.tim.2017.06.003
Loni Townsley , Elizabeth A. Shank

Cell–cell communication enables bacteria to coordinate their behavior through the production, recognition, and response to chemical signals produced by their microbial neighbors. An important example of coordinated behavior in bacteria is biofilm formation, where individual cells organize into highly complex, matrix-encased communities that differentiate into distinct cell types and divide labor among individual cells. Bacteria rely on environmental cues to influence biofilm development, including chemical cues produced by other microbes. A multitude of recent studies have demonstrated that natural-product antibiotics at subinhibitory concentrations can impact biofilm formation in neighboring microbes, supporting the hypothesis that these compounds may have evolved as signaling molecules that mediate cell–cell interactions. In this review we discuss the role of antibiotics in modulating biofilm formation and interspecies communication in bacteria.



中文翻译:

天然产物抗生素:调节细菌生物膜形成的线索

细胞间的通讯使细菌能够通过微生物邻居产生的化学信号的产生,识别和响应来协调其行为。细菌协调行为的一个重要例子是生物膜形成,其中单个细胞组织成高度复杂的,基质包裹的社区,这些社区分化成不同的细胞类型并在单个细胞之间分配劳力。细菌依赖于环境线索来影响生物膜的发育,包括其他微生物产生的化学线索。大量最新研究表明,亚抑制浓度的天然产物抗生素可影响邻近微生物的生物膜形成,支持以下假设:这些化合物可能已作为介导细胞间相互作用的信号分子而进化。

更新日期:2017-07-05
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