Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology. Changes in synaptic excitation and inhibition in schizophrenia disrupt delta rhythm-mediated cortico-cortical communication, while enhancing thalamocortical communication in this frequency band. The contrasting relationships between delta and higher frequencies in thalamus and cortex generate frequency mismatches in inter-regional connectivity, leading to a disruption in temporal communication between higher-order brain regions associated with mental time travel.

中文翻译：

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精神分裂症的异常网络活动

与精神分裂症相关的脑动态变化在很大程度上是模棱两可的，解释复杂的因素很多，例如治疗药物的存在和综合征本身的复杂性。所有患者共享的个体网络振荡在大脑范围内发生变化的证据在很大程度上是模棱两可的，但较低（delta）波段比较高（gamma）波段更强。然而，跨多个、相互依赖、嵌套频率的特定区域节律变化可能与病理学更好地相关。精神分裂症中突触激发和抑制的变化破坏了 delta 节律介导的皮质-皮质通信，同时增强了该频带中的丘脑皮质通信。