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Improving our understanding, and detection, of glaucomatous damage: An approach based upon optical coherence tomography (OCT)
Progress in Retinal and Eye Research ( IF 17.8 ) Pub Date : 2016-12-22 , DOI: 10.1016/j.preteyeres.2016.12.002
Donald C. Hood

Although ophthalmologists are becoming increasingly reliant upon optical coherence tomography (OCT), clinicians who care for glaucoma patients are not taking full advantage of the potential of this powerful technology. First, we ask, how would one describe the nature of glaucomatous damage if only OCT scans were available? In particular, a schematic model of glaucomatous damage is developed in section 2, and the nature of glaucomatous damage seen on OCT scans described in the context of this model in section 3. In particular, we illustrate that local thinning of the circumpapillary retinal nerve fiber layer (cpRNFL) around the optic disc can vary in location, depth, and/or width, as well as homogeneity of damage. Second, we seek to better understand the relationship between the thinning of the cpRNFL and the various patterns of sensitivity loss seen on visual fields obtained with standard automated perimetry. In sections 4 and 5, we illustrate why one should expect a wide range of visual field patterns, and iilustrate why they should not be placed into discrete categories. Finally, section 6 describes how the clinician can take better advantage of the information in OCT scans. The approach is summarized in a single-page report, which can be generated from a single wide-field scan. The superiority of this approach, as opposed to the typical reliance on summary metrics, is described.



中文翻译:

增进我们对青光眼损害的了解和发现:一种基于光学相干断层扫描(OCT)的方法

尽管眼科医生越来越依赖光学相干断层扫描(OCT),但是照顾青光眼患者的临床医生并未充分利用这一强大技术的潜力。首先,我们问,如果仅进行OCT扫描,将如何描述青光眼损害的性质?特别是,在第2节中开发了青光眼损害的示意图模型,在第3节中描述了在该模型的上下文中描述的在OCT扫描上看到的青光眼损害的性质。特别是,我们说明了眼睑周围视网膜神经纤维的局部变薄光盘周围的CDRNFL层(cpRNFL)的位置,深度和/或宽度以及损坏的均匀性可能会有所不同。第二,我们试图更好地了解cpRNFL的变薄与使用标准自动视野检查仪获得的视野中看到的各种灵敏度损失模式之间的关系。在第4节和第5节中,我们说明了为什么人们应该期待各种各样的视野模式,并说明了为什么不应该将它们放在离散的类别中。最后,第6节介绍了临床医生如何更好地利用OCT扫描中的信息。该方法在单页报告中进行了总结,该报告可以通过单次宽域扫描生成。描述了这种方法的优越性,与通常依赖于摘要指标相反。并说明为什么不应将它们放在离散的类别中。最后,第6节介绍了临床医生如何更好地利用OCT扫描中的信息。该方法在单页报告中进行了总结,该报告可以通过单次宽域扫描生成。描述了这种方法的优越性,与通常依赖于摘要指标相反。并说明为什么不应将它们放在离散的类别中。最后,第6节介绍了临床医生如何更好地利用OCT扫描中的信息。该方法在单页报告中进行了总结,该报告可以通过单次宽域扫描生成。描述了这种方法的优越性,与通常依赖于摘要指标相反。

更新日期:2016-12-22
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