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Immunomodulatory Properties of Plants and Mushrooms
Trends in Pharmacological Sciences ( IF 13.8 ) Pub Date : 2017-08-30 , DOI: 10.1016/j.tips.2017.07.006
Jan Martel , Yun-Fei Ko , David M. Ojcius , Chia-Chen Lu , Chih-Jung Chang , Chuan-Sheng Lin , Hsin-Chih Lai , John D. Young

Plants and mushrooms are used for medicinal purposes and the screening of molecules possessing biological activities. A single plant or mushroom may produce both stimulatory and inhibitory effects on immune cells, depending on experimental conditions, but the reason behind this dichotomy remains obscure. We present here a large body of experimental data showing that water extracts of plants and mushrooms usually activate immune cells, whereas ethanol extracts inhibit immune cells. The mode of extraction of plants and mushrooms may thus determine the effects produced on immune cells, possibly due to differential solubility and potency of stimulatory and inhibitory compounds. We also examine the possibility of using such plant and mushroom extracts to treat immune system disorders.



中文翻译:

植物和蘑菇的免疫调节特性

植物和蘑菇用于医学目的和筛选具有生物活性的分子。取决于实验条件,单一植物或蘑菇可能会对免疫细胞产生刺激和抑制作用,但这种二分法背后的原因仍然不清楚。我们在这里提供了大量的实验数据,这些数据表明植物和蘑菇的水提取物通常会激活免疫细胞,而乙醇提取物会抑制免疫细胞。因此,植物和蘑菇的提取方式可以确定对免疫细胞产生的作用,这可能是由于刺激性和抑制性化合物的溶解度和效力不同所致。我们还研究了使用这种植物和蘑菇提取物治疗免疫系统疾病的可能性。

更新日期:2017-08-30
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