There are currently no disease-modifying therapies for the treatment of tauopathies, a group of progressive neurodegenerative disorders that are pathologically defined by the presence of tau protein aggregates in the brain. Current challenges for the treatment of tauopathies include the inability to diagnose early and to confidently discriminate between distinct tauopathies in patients, alongside an incomplete understanding of the cellular mechanisms involved in pathogenic tau-induced neuronal death and dysfunction. In this review, we describe current diagnostic and therapeutic strategies, known drivers of pathogenic tau formation, recent contributions to our current mechanistic understanding of how pathogenic tau induces neuronal death, and potential diagnostic and therapeutic approaches.

当前，尚无用于治疗tauopathies的疾病改良疗法，tauopathies是一组进行性神经退行性疾病，在病理上由脑中tau蛋白聚集体的存在来定义。目前治疗tauopathies的挑战包括无法及早诊断和无法自信地区分患者不同的tauopathies，以及对与致病性tau诱导的神经元死亡和功能障碍有关的细胞机制的不完全了解。在这篇综述中，我们描述了当前的诊断和治疗策略，致病性tau形成的已知驱动因素，对我们目前对致病性tau如何诱导神经元死亡的机制的最新了解以及潜在的诊断和治疗方法。