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Development of Selective Peptide Catalysts with Secondary Structural Frameworks
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2017-09-05 00:00:00 , DOI: 10.1021/acs.accounts.7b00211
Kengo Akagawa 1 , Kazuaki Kudo 1
Affiliation  

Enzymes are biogenic catalysts that enable the vital activity of organisms. Enzymes promote reactions in a selective manner with a high level of substrate recognition ability. The development of such a sophisticated catalyst has been one of the goals for chemists. A synthetic peptide is the prime candidate to realize an enzyme-like catalyst. Considering that the catalytic function of enzymes derives from their molecular structures, the key for the creation of a peptide catalyst might be the introduction of a specific three-dimensional structure. Our motivation was to find a peptide catalyst with a versatile secondary structural framework and apply the peptide to a variety of selective reactions.

中文翻译:

具有二级结构框架的选择性肽催化剂的开发

酶是能够使生物发挥重要生命作用的生物催化剂。酶以高水平的底物识别能力以选择性方式促进反应。开发这种复杂的催化剂一直是化学家的目标之一。合成肽是实现酶样催化剂的主要候选者。考虑到酶的催化功能源于它们的分子结构,创建肽催化剂的关键可能是引入特定的三维结构。我们的动机是寻找一种具有通用二级结构框架的肽催化剂,并将该肽应用于各种选择性反应。
更新日期:2017-09-05
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