The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h²_SNP) for European-American females of 29% that is similar to h²_SNP for schizophrenia and is substantially higher than h²_SNP in European-American males (estimate not distinguishable from zero). We found strong evidence of overlapping genetic risk between PTSD and schizophrenia along with more modest evidence of overlap with bipolar and major depressive disorder. No single-nucleotide polymorphisms (SNPs) exceeded genome-wide significance in the transethnic (overall) meta-analysis and we do not replicate previously reported associations. Still, SNP-level summary statistics made available here afford the best-available molecular genetic index of PTSD-for both European- and African-American individuals-and can be used in polygenic risk prediction and genetic correlation studies of diverse phenotypes. Publication of summary statistics for ∼10 000 African Americans contributes to the broader goal of increased ancestral diversity in genomic data resources. In sum, the results demonstrate genetic influences on the development of PTSD, identify shared genetic risk between PTSD and other psychiatric disorders and highlight the importance of multiethnic/racial samples. As has been the case with schizophrenia and other complex genetic disorders, larger sample sizes are needed to identify specific risk loci.

中文翻译：

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PTSD的最大GWAS（N = 20 070）产生与精神分裂症的遗传重叠以及遗传力的性别差异。

精神病学基因组-创伤后应激障碍小组（PGC-PTSD）结合了11个多种族研究的全基因组病例对照分子遗传数据，以量化PTSD的遗传力，以检查精神分裂症，双相情感障碍和重度抑郁症的潜在共同遗传风险，以及以确定PTSD的风险位点。检查了20 730个个体，我们报告了29％的欧洲女性基于分子遗传学的遗传力估计值（h ² _SNP），与精神分裂症的h ² _SNP相似，并且显着高于h ² _SNP在欧美男性中（估计值无法与零区分开）。我们发现强有力的证据表明，PTSD和精神分裂症之间存在重叠的遗传风险，同时也存在与双相情感障碍和重度抑郁症重叠的更为适度的证据。在跨种族（整体）荟萃分析中，没有单核苷酸多态性（SNP）超过全基因组范围的重要性，并且我们不重复先前报道的关联。尽管如此，这里提供的SNP级汇总统计数据为PTSD的欧洲和非裔美国人个体提供了最佳的分子遗传指数，并且可以用于多种表型的多基因风险预测和遗传相关性研究。出版约10,000名非裔美国人的摘要统计数据有助于实现更广泛的目标，即增加基因组数据资源中的祖先多样性。总共，结果表明遗传因素对PTSD的发展有影响，确定了PTSD与其他精神疾病之间的共同遗传风险，并突出了多种族/种族样本的重要性。与精神分裂症和其他复杂的遗传疾病一样，需要更大的样本量才能确定特定的风险基因座。