Purpose: Based on the clinical relevance of the chemokine receptor 4 (CXCR4) as a molecular target in cancer and on the success of [⁶⁸Ga]pentixafor as an imaging probe for high-contrast visualization of CXCR4-expression, the spectrum of clinical CXCR4-targeting was expanded towards peptide receptor radionuclide therapy (PRRT) by the development of [¹⁷⁷Lu]pentixather.

中文翻译：

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[ ¹⁷⁷ Lu] pentixather：第一种CXCR4定向内放射治疗剂的全面临床前表征

目的：基于趋化因子受体4（CXCR4）作为癌症分子靶标的临床相关性以及[ ⁶⁸ Ga] pentixafor作为用于高对比度可视化CXCR4表达的成像探针的成功经验，临床CXCR4的光谱[ ¹⁷⁷ Lu] pentixather的开发使靶向作用扩展到了肽受体放射性核素治疗（PRRT）。