Fluorescein is modified to bear ¹⁸F so that it can act as both a positron emitter, and a fluorophore, allowing detection by positron emission tomography (PET), scintillation, and fluorescent imaging (FL). [¹⁸F]-2 is injected into the intrathecal space of rats and used to observe the cerebrospinal fluid (CSF) that bathes the brain and spine. Injury in three different applications is visualized with [¹⁸F]-2: 1) detection of a 0.7 mm paranasal-sinus CSF leak (CSFL); 2) detection of 0.5 mm puncture damage to the thoracic spine (acute spinal cord injury); and 3) detection of intracerebral hemorrhage/edema because of traumatic brain injury. In all models, the location of injury is visualized with [¹⁸F]-2 at high resolution. [¹⁸F]-2 PET imaging may be a superior alternative to current clinical contrast myelography and ¹³¹I, ¹¹¹In or ^99mTc radionuclide cisternography. Like fluorescein, [¹⁸F]-2 may also have other uses in diagnostic or fluorescence guided medicine.

中文翻译：

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[ ¹⁸ F]-正电子发射荧光，脑脊液探针，用于成像对大脑和脊柱的损伤

荧光素经过修饰，可以承受¹⁸ F，因此它既可以充当正电子发射体，又可以充当荧光团，从而可以通过正电子发射断层扫描（PET），闪烁和荧光成像（FL）进行检测。将[ ¹⁸ F] -2注射到大鼠的鞘内腔中，并用于观察浸润大脑和脊柱的脑脊液（CSF）。通过[ ¹⁸ F] -2可以看到三种不同应用中的伤害：1）检测到0.7毫米的鼻旁窦CSF泄漏（CSFL）；2）检测到0.5毫米的胸椎穿刺损伤（急性脊髓损伤）；3）由于脑外伤而导致的脑出血/水肿的检测。在所有模型中，受伤的位置均可通过[ ¹⁸F] -2（高分辨率）。[ ¹⁸ F] -2 PET成像可能是当前临床对比造影和¹³¹ I，¹¹¹ In或^99m Tc放射性核素水肿成像的更好替代方法。像荧光素一样，[ ¹⁸ F] -2在诊断或荧光引导医学中也可能有其他用途。