当前位置: X-MOL 学术Endocr. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions
Endocrine Reviews ( IF 20.3 ) Pub Date : 2017-08-30 , DOI: 10.1210/er.2017-00163
Abdikarim Abdullahi 1, 2, 3 , Marc G Jeschke 1, 2, 3, 4
Affiliation  

In this era of increased obesity and diabetes prevalence, the browning of white adipose tissue (WAT) has emerged as a promising therapeutic target to induce weight loss and improve insulin sensitivity in this population. The browning process entails a shift in the WAT from primarily storing excess energy to the dissipation of energy as heat. However, this idealistic view of WAT browning being the savior of the metabolic syndrome has been criticized by studies in burn and cancer patients that have shown browning to be detrimental rather than beneficial. In fact, in the context of hypermetabolic states, the browning of WAT has presented with substantial clinical adverse outcomes related to cachexia, hepatic steatosis, and muscle catabolism. Therefore, the previous thought construct of understanding browning as an all-beneficial physiologic event has now been met with skepticism. In this review, we focus on current knowledge of browning of WAT and its adverse metabolic alterations during hypermetabolic states. We also discuss the regulators and signaling pathways involved in the browning process and their potential for being targeted by new or existing drugs to inhibit or alleviate browning, potentially leading to decreased hypermetabolism and improved clinical outcomes. Lastly, the imminent clinical applications of pharmacological agents are explored in the perspective of attenuating WAT browning and its associated adverse side effects reported in burn patients.

中文翻译:

驯服火焰:针对代谢异常的白色脂肪组织褐变

在肥胖和糖尿病患病率上升的时代,褐变的白色脂肪组织(WAT)已成为一种有希望的治疗靶标,以诱导体重减轻和改善该人群的胰岛素敏感性。褐变过程使WAT从最初存储多余的能量转变为以热量消散的方式。然而,WAT褐变是代谢综合症的救星的这种理想主义观点已被烧伤和癌症患者的研究所批评,这些研究表明褐变是有害的而不是有益的。实际上,在代谢过度的情况下,WAT的褐变已呈现出与恶病质,肝脂肪变性和肌肉分解代谢有关的大量临床不良后果。所以,先前将褐变理解为有益的生理事件的思想构想遭到了质疑。在这篇综述中,我们重点关注代谢旺盛状态下WAT褐变及其不利的代谢变化的最新知识。我们还讨论了褐变过程中涉及的调节剂和信号传导途径,以及它们被新药或现有药物靶向抑制或缓解褐变的潜力,可能导致代谢减少和临床结果改善。最后,从减轻WAT褐变及其在烧伤患者中报告的相关不良副作用的角度出发,探索了即将使用的药理学药物。我们专注于当前的WAT褐变及其在代谢异常状态下不利的代谢变化的知识。我们还讨论了褐变过程中涉及的调节剂和信号传导途径,以及它们被新药或现有药物靶向抑制或缓解褐变的潜力,可能导致代谢减少和临床结果改善。最后,从减轻WAT褐变及其在烧伤患者中报告的相关不良副作用的角度出发,探索了即将使用的药理学药物。我们专注于当前的WAT褐变及其在代谢异常状态下不利的代谢变化的知识。我们还讨论了褐变过程中涉及的调节剂和信号传导途径,以及它们被新药或现有药物靶向抑制或缓解褐变的潜力,可能导致代谢减少和临床结果改善。最后,从减轻WAT褐变及其在烧伤患者中报告的相关不良副作用的角度出发,探索了即将使用的药理学药物。可能会导致代谢亢进的减少和临床结果的改善。最后,从减轻WAT褐变及其在烧伤患者中报告的相关不良副作用的角度出发,探索了即将使用的药理学药物。可能会导致代谢亢进的减少和临床结果的改善。最后,从减轻WAT褐变及其在烧伤患者中报告的相关不良副作用的角度出发,探索了即将使用的药理学药物。
更新日期:2017-08-30
down
wechat
bug