In this study, we used insurance claims for over one-third of the entire US population to create a subset of 128,989 families (481,657 unique individuals). We then used these data to (i) estimate the heritability and familial environmental patterns of 149 diseases and (ii) infer the genetic and environmental correlations for disease pairs from a set of 29 complex diseases. The majority (52 of 65) of our study's heritability estimates matched earlier reports, and 84 of our estimates appear to have been obtained for the first time. We used correlation matrices to compute environmental and genetic disease classifications and corresponding reliability measures. Among unexpected observations, we found that migraine, typically classified as a disease of the central nervous system, appeared to be most genetically similar to irritable bowel syndrome and most environmentally similar to cystitis and urethritis, all of which are inflammatory diseases.

中文翻译：

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根据共同的遗传和环境决定因素对常见人类疾病进行分类。

在这项研究中，我们使用超过三分之一的美国人口的保险索赔来创建 128,989 个家庭（481,657 个独特个体）的子集。然后，我们使用这些数据 (i) 估计 149 种疾病的遗传力和家族环境模式，以及 (ii) 从 29 种复杂疾病中推断疾病对的遗传和环境相关性。我们研究的大多数（65 项中的 52 项）遗传力估计值与之前的报告相匹配，并且我们的估计值中有 84 项似乎是首次获得。我们使用相关矩阵来计算环境和遗传疾病分类以及相应的可靠性度量。在意想不到的观察中，我们发现偏头痛（通常被归类为中枢神经系统疾病）似乎在基因上与肠易激综合症最相似，在环境上与膀胱炎和尿道炎最相似，所有这些都是炎症性疾病。