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Fibroblast Growth Factor 21 - Metabolic Role in Mice and Men
Endocrine Reviews ( IF 20.3 ) Pub Date : 2017-07-28 , DOI: 10.1210/er.2017-00016
Harald Staiger 1, 2, 3, 4, 5 , Michaela Keuper 4, 5 , Lucia Berti 3, 4, 5 , Martin Hrabě de Angelis 4, 5, 6 , Hans-Ulrich Häring 2, 3, 5, 7
Affiliation  

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very robust data documenting this factor’s favorable effects on glucose and lipid metabolism in mice. For more than ten years now, intense in vivo and ex vivo experimentation addressed the physiological functions of FGF21 in humans as well as its pathophysiological role and pharmacological effects in human metabolic disease. This work produced a comprehensive collection of data revealing overlaps in FGF21 expression and function but also significant differences between mice and men that have to be considered before translation from bench to bedside can be successful. This review summarizes what is known about FGF21 in mice and humans with a special focus on this factor’s role in glucose and lipid metabolism and in metabolic diseases, such as obesity and type-2 diabetes mellitus. We highlight the discrepancies between mice and men and try to decipher their underlying reasons.

中文翻译:

成纤维细胞生长因子21-在小鼠和男性中的代谢作用

自从2000年鉴定以来,科学家对肝因子成纤维细胞生长因子(FGF)21的兴趣已大大增加,并且仍然很高,这是由于大量非常可靠的数据证明了该因子对小鼠葡萄糖和脂质代谢的有利作用。十多年来,体内离体细胞都非常紧张实验探讨了FGF21在人类中的生理功能及其在人类代谢疾病中的病理生理作用和药理作用。这项工作收集了完整的数据,揭示了FGF21表达和功能的重叠,但是成功完成从长凳到床头的翻译之前必须考虑的小鼠和男性之间的显着差异。这篇综述总结了小鼠和人类对FGF21的了解,特别关注了该因子在葡萄糖和脂质代谢以及代谢性疾病(例如肥胖症和2型糖尿病)中的作用。我们着重指出小鼠和男人之间的差异,并试图解释其根本原因。
更新日期:2017-08-24
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