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Spatial and Temporal Control of Senescence
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2017-08-17 , DOI: 10.1016/j.tcb.2017.07.004
Yoko Ito , Matthew Hoare , Masashi Narita

Cellular senescence is an autonomous tumor suppressor mechanism leading to stable cell cycle arrest. Senescent cells are highly secretory, driving a range of different functions through the senescence-associated secretory phenotype (SASP). Recent findings have suggested that the composition of the SASP is dynamically and spatially regulated and that the changing composition of the SASP can determine the beneficial and detrimental aspects of the senescence program, tipping the balance to either an immunosuppressive/profibrotic environment or proinflammatory/fibrolytic state. Here, we discuss the current understanding of the temporal and spatial regulation of the SASP and the novel finding of NOTCH signaling as a regulator of SASP composition.



中文翻译:

衰老的时空控制

细胞衰老是导致稳定的细胞周期停滞的自主肿瘤抑制机制。衰老细胞高度分泌,通过衰老相关的分泌表型(SASP)驱动一系列不同的功能。最近的发现表明,SASP的组成是动态和空间调节的,SASP组成的变化可以确定衰老程序的有益和有害方面,从而使平衡达到免疫抑制/纤维化环境或促炎/纤维化状态。在这里,我们讨论当前对SASP的时空调节的理解以及NOTCH信号作为SASP组成调节剂的新颖发现。

更新日期:2017-08-17
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