The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or terminally commit to a cell specification program. To guide their decisions, stem cells make frequent use of ubiquitylation, a post-translational modification that can affect the activity, interaction landscape, or stability of stem cell proteins. In this review we discuss novel findings that have provided insight into ubiquitin-dependent mechanisms of stem cell control and revealed how an essential and highly conserved protein modification can shape metazoan development.

中文翻译：

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干细胞生物学的泛素依赖性调节

后生动物体的生长依赖于干细胞一系列高度协调的细胞命运决定，这些决定可以进行自我更新，可逆地进入静止状态，或最终致力于细胞规范程序。为了指导其决策，干细胞经常使用泛素化，这是一种翻译后修饰，可以影响干细胞蛋白质的活性、相互作用景观或稳定性。在这篇综述中，我们讨论了新的发现，这些发现深入了解了干细胞控制的泛素依赖性机制，并揭示了一种重要且高度保守的蛋白质修饰如何塑造后生动物的发育。