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α-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2017-03-02 , DOI: 10.1016/j.tcb.2017.02.002
Janin Lautenschläger 1 , Clemens F Kaminski 1 , Gabriele S Kaminski Schierle 1
Affiliation  

α-Synuclein is known as a presynaptic protein that binds to small synaptic vesicles. Recent studies suggest that α-synuclein is not only attracted to these tiny and therewith highly curved membranes, but that in fact the sensing and regulation of membrane curvature is part of its physiological function. Moreover, recent studies have suggested that α-synuclein plays a role in the endocytosis of synaptic vesicles, and have provided support for a function of α-synuclein during exo- and endocytosis in which curvature sensing and membrane stabilization are crucial steps. This review aims to highlight recent research in the field and adds a new picture on the function of α-synuclein in maintaining synaptic homeostasis upon intense and repetitive neuronal activity.



中文翻译:

α-突触核蛋白——胞吐作用、内吞作用或两者兼而有之的调节剂?

α-突触核蛋白被称为与小突触小泡结合的突触前蛋白。最近的研究表明,α-突触核蛋白不仅被这些微小且高度弯曲的膜所吸引,而且事实上膜曲率的感知和调节是其生理功能的一部分。此外,最近的研究表明,α-突触核蛋白在突触小泡的内吞作用中起作用,并为 α-突触核蛋白在胞吐和内吞过程中的功能提供了支持,其中曲率传感和膜稳定是关键步骤。这篇综述旨在突出该领域的最新研究,并为 α-突触核蛋白在强烈和重复的神经元活动中维持突触稳态的功能添加新的图景。

更新日期:2017-03-02
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