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Inhibitory Plasticity: Balance, Control, and Codependence
Annual Review of Neuroscience ( IF 13.9 ) Pub Date : 2017-08-03 00:00:00 , DOI: 10.1146/annurev-neuro-072116-031005
Guillaume Hennequin 1 , Everton J. Agnes 2 , Tim P. Vogels 2
Affiliation  

Inhibitory neurons, although relatively few in number, exert powerful control over brain circuits. They stabilize network activity in the face of strong feedback excitation and actively engage in computations. Recent studies reveal the importance of a precise balance of excitation and inhibition in neural circuits, which often requires exquisite fine-tuning of inhibitory connections. We review inhibitory synaptic plasticity and its roles in shaping both feedforward and feedback control. We discuss the necessity of complex, codependent plasticity mechanisms to build nontrivial, functioning networks, and we end by summarizing experimental evidence of such interactions.

中文翻译:


抑制性可塑性:平衡,控制和相互依赖

抑制性神经元虽然数量相对较少,但对大脑回路具有强大的控制作用。面对强大的反馈激励,它们可以稳定网络活动,并积极参与计算。最近的研究揭示了神经回路中激发和抑制的精确平衡的重要性,这通常需要对抑制性连接进行精细的微调。我们审查抑制突触可塑性及其在塑造前馈和反馈控制中的作用。我们讨论了复杂,相互依存的可塑性机制构建非平凡的,可运行的网络的必要性,最后我们总结了这种相互作用的实验证据。

更新日期:2017-08-03
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