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What Have We Learned About Movement Disorders from Functional Neurosurgery?
Annual Review of Neuroscience ( IF 13.9 ) Pub Date : 2017-08-03 00:00:00 , DOI: 10.1146/annurev-neuro-070815-013906
Andres M. Lozano 1, 2 , William D. Hutchison 1, 2 , Suneil K. Kalia 1, 2
Affiliation  

Modern functional neurosurgery for movement disorders such as Parkinson's disease, tremor, and dystonia involves the placement of focal lesions or the application of deep brain stimulation (DBS) within circuits that modulate motor function. Precise targeting of these motor structures can be further refined by the use of electrophysiological approaches. In particular, microelectrode recordings enable the delineation of neuroanatomic structures. In the course of these operations, there is an opportunity not only to map basal ganglia structures but also to gain insights into how disturbances in neural activity produce movement disorders. In this review, we aim to highlight what the field has uncovered thus far about movement disorders through DBS. The work to date lays the foundation for future studies that will shed further light on dysfunctional circuits mediating diseases of the nervous system and how we might modulate these circuits therapeutically.

中文翻译:


我们从功能性神经外科中学到了什么运动障碍?

用于运动障碍(例如帕金森氏病,震颤和肌张力障碍)的现代功能性神经外科手术涉及在控制运动功能的回路中放置局灶性病变或应用深部脑刺激(DBS)。这些运动结构的精确定位可以通过使用电生理方法来进一步完善。特别地,微电极记录使得能够描绘神经解剖结构。在这些操作过程中,不仅有机会绘制基底神经节的结构图,而且有机会了解神经活动的紊乱如何产生运动障碍。在这篇综述中,我们旨在强调迄今为止通过DBS进行的运动障碍领域尚未发现的内容。

更新日期:2017-08-03
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