The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms that enable neoplastic cells to invade the local microenvironment, reach the circulation, and colonize distant sites, including the so-called epithelial-to-mesenchymal transition. Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immunosurveillance. Here, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemination, and present potential therapeutic approaches to prevent or target metastatic disease by harnessing NK cells.

中文翻译：

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NK细胞转移的控制。

恶性细胞向远处解剖位置的转移扩散是癌症相关死亡的重要原因。转移受癌细胞内在机制控制，该机制可使肿瘤细胞侵入局部微环境，到达循环系统，并在远处定居，包括所谓的上皮到间质转化。而且，转移是通过微环境和全身过程例如免疫监视来调节的。在这里，我们概述了调节转移的癌细胞内在和外在因素，讨论了自然杀伤（NK）细胞在转移控制中的关键作用，并提出了利用NK预防或靶向转移性疾病的潜在治疗方法细胞。