Surface-enhanced Raman scattering (SERS) is of interest for biomedical analysis and imaging because of its sensitivity, specificity and multiplexing capabilities. The successful application of SERS for in vivo biosensing requires probes to be biocompatible and procedures to be minimally invasive, challenges that have respectively been met by developing new nanoprobes and instrumentation. This Review presents recent developments in these areas, describing case studies in which sensors have been implemented, as well as outlining shortcomings that must be addressed before SERS sees clinical use.

中文翻译：

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表面增强拉曼光谱用于体内生物传感

表面增强拉曼散射（SERS）由于其灵敏度，特异性和多路复用能力而引起了生物医学分析和成像的兴趣。SERS在体内生物传感中的成功应用要求探针具有生物相容性，并且程序必须具有微创性，开发新的纳米探针和仪器已分别解决了挑战。这篇综述介绍了这些领域的最新发展，描述了已实施传感器的案例研究，并概述了在SERS应用于临床之前必须解决的缺点。