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Evolution of macromolecular complexity in drug delivery systems.
Nature Reviews Chemistry ( IF 36.3 ) Pub Date : 2017-08-09 , DOI: 10.1038/s41570-017-0063
Ashok Kakkar 1, 2 , Giovanni Traverso 1, 3 , Omid C Farokhzad 4 , Ralph Weissleder 5 , Robert Langer 1
Affiliation  

Designing therapeutics is a process with many challenges. Even if the first hurdle - designing a drug that modulates the action of a particular biological target in vitro - is overcome, selective delivery to that target in vivo presents a major barrier. Side-effects can, in many cases, result from the need to use higher doses without targeted delivery. However, the established use of macromolecules to encapsulate or conjugate drugs can provide improved delivery, and stands to enable better therapeutic outcomes. In this Review, we discuss how drug delivery approaches have evolved alongside our ability to prepare increasingly complex macromolecular architectures. We examine how this increased complexity has overcome the challenges of drug delivery and discuss its potential for fulfilling unmet needs in nanomedicine.

中文翻译:

药物输送系统中大分子复杂性的演变。

设计治疗方法是一个充满挑战的过程。即使克服了第一个障碍-设计一种可在体外调节特定生物靶标作用的药物-,但在体内选择性递送至该靶标还是一个主要障碍。在许多情况下,副作用可能是由于需要使用更高剂量而不需要有针对性的递送而引起的。然而,将大分子用于包封或结合药物的确定用途可以提供改善的递送,并且能够实现更好的治疗效果。在这篇评论中,我们讨论了药物递送方法是如何随着我们制备日益复杂的大分子结构的能力而发展的。我们研究了这种日益增加的复杂性如何克服了药物输送的挑战,并讨论了其满足纳米医学未满足需求的潜力。
更新日期:2017-08-09
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