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Functional polymer surfaces for controlling cell behaviors
Materials Today ( IF 24.2 ) Pub Date : 2018-01-01 , DOI: 10.1016/j.mattod.2017.07.002
Lina Chen , Casey Yan , Zijian Zheng

Thorough understanding of how to control cell behaviors including cell adhesion, orientation, migration and differentiation on an artificial surface is critical in materials and life sciences such as advanced biomedical engineering, tissue engineering, and cell-based bioassay. In nature, extracellular matrix (ECM) plays an important role in controlling cell behaviors. It can not only provide the cells with mechanical support but also profoundly affect cell functions such as metabolism, movement and transport process. Functional polymer surface exhibits superior advantages over many other materials for use as artificial ECM owing to its excellent mechanical properties, abundant chemical species and remarkable capability to form various topographical surfaces. In particular, surface chemistry, mechanical properties and topography of these functional polymers are found to be three major parameters for effective control of cell behaviors. This paper comprehensively reviews the fundamental understanding of functional polymer surfaces for controlling cell behaviors. Different fabrication methods to achieve functional polymer surfaces and the parameters for effective control of cell behaviors are discussed. The future prospects and challenges particularly in cell biomedical engineering are also discussed at the end of this review paper.

中文翻译:

用于控制细胞行为的功能性聚合物表面

彻底了解如何控制人工表面上的细胞行为(包括细胞粘附、定向、迁移和分化)对于材料和生命科学(例如高级生物医学工程、组织工程和基于细胞的生物测定)至关重要。在自然界中,细胞外基质 (ECM) 在控制细胞行为方面起着重要作用。它不仅可以为细胞提供机械支撑,还可以深刻影响细胞的新陈代谢、运动和运输过程等功能。功能性聚合物表面由于其优异的机械性能、丰富的化学物种和形成各种形貌表面的非凡能力,在用作人工 ECM 的许多其他材料中表现出优越的优势。特别是表面化学,发现这些功能聚合物的机械性能和形貌是有效控制细胞行为的三个主要参数。本文全面回顾了对控制细胞行为的功能性聚合物表面的基本理解。讨论了实现功能性聚合物表面的不同制造方法和有效控制细胞行为的参数。本综述的结尾还讨论了未来的前景和挑战,特别是在细胞生物医学工程方面。讨论了实现功能性聚合物表面的不同制造方法和有效控制细胞行为的参数。本综述的结尾还讨论了未来的前景和挑战,特别是在细胞生物医学工程方面。讨论了实现功能性聚合物表面的不同制造方法和有效控制细胞行为的参数。本综述的结尾还讨论了未来的前景和挑战,特别是在细胞生物医学工程方面。
更新日期:2018-01-01
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