Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.

中文翻译：

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蛋白质稳态的小分子调节

通过基于核酸的技术控制蛋白质水平已被证明是一种有用的研究工具，但在细胞通透性，时间控制和潜在的治疗方法方面缺乏小分子的优势。在这篇综述中，我们讨论了可用于控制小分子细胞内蛋白质水平的技术，并比较了各种可用系统。