Near-infrared (NIR)-induced chemothermal doxorubicin (DOX) release for anticancer activity was demonstrated using DOX-incorporated fully lateral nanodimensional graphene oxide (nGO) flakes layered with chitosan-polyethylene glycol (PEG) conjugate (nGO@DOX-cPEG) from a single-pass gas-phase self-assembly. Unlike most previously reported graphene oxide-based drug carriers, the proposed processing method introduced a fully nanoscale (both in lateral dimension and thickness) configuration without multistep wet physicochemical processes that enhance the drug-loading capacity and NIR-induced heat generation resulting from the increased surface area. The accumulation of nGO@DOX-cPEG flakes in prostate cancer cells enhanced apoptotic phenomena via the combined effects of DOX release and heat generation upon NIR irradiation. The combined anticancer effects were verified through in vivo assessment with better safety profiles than free DOX. The proposed strategy warrants continuous assembly of multimodal nanocarriers for the efficient treatment of prostate cancers and may be a promising candidate for advanced drug delivery systems.

使用掺有壳聚糖-聚乙二醇（PEG）共轭物（nGO @ DOX-cPEG）的DOX掺入的全侧向纳米级氧化石墨烯（nGO）薄片证明了近红外（NIR）诱导的化学阿霉素（DOX）释放的抗癌活性。单程气相自组装。与以前报道的大多数基于氧化石墨烯的药物载体不同，拟议的加工方法引入了完全纳米级（横向尺寸和厚度）构型，而没有多步湿式物理化学过程，从而增加了载药量和NIR诱导的热量增加。表面积。nGO @ DOX-cPEG薄片在前列腺癌细胞中的积累通过DOX释放和近红外辐射产生热量的联合作用增强了凋亡现象。体内评估具有比免费DOX更好的安全性。提出的策略保证了多峰纳米载体的连续组装以有效治疗前列腺癌，并且可能是先进药物递送系统的有希望的候选者。