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A metal–semiconductor nanocomposite as an efficient oxygen-independent photosensitizer for photodynamic tumor therapy
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2017-07-12 00:00:00 , DOI: 10.1039/c7nh00087a
Jin-Xuan Fan 1, 2, 3, 4 , Miao-Deng Liu 1, 2, 3, 4 , Chu-Xin Li 1, 2, 3, 4 , Sheng Hong 1, 2, 3, 4 , Di-Wei Zheng 1, 2, 3, 4 , Xin-Hua Liu 1, 2, 3, 4 , Si Chen 1, 2, 3, 4 , Hong Cheng 1, 2, 3, 4 , Xian-Zheng Zhang 1, 2, 3, 4
Affiliation  

Photodynamic therapy (PDT) is regarded as one of the most promising cancer treatments, and oxygen-independent photosensitizers have been intensively explored for advancing the development of PDT. Here, we reported on a superior hybrid nanocomposite (HNC) consisting of a metal (Au deposition) and a semiconductor (CdSe-seeded/CdS nanorods) as a photosensitizer. Under visible light, the photogenerated holes were three-dimensionally confined to the CdSe quantum dots and the delocalized electrons were transferred to the Au tips, which provided hydrogen and oxygen evolution sites for water splitting to generate reactive oxygen species (ROS) with no need for oxygen participation. Compared with semiconductors without deposited metal (i.e. raw CdSe-seeded/CdS nanorods (NRs)) under a normoxic or hypoxic environment, the HNCs exhibited substantially enhanced light-triggered ROS generation in vitro. After being modified with an Arg-Gly-Asp (RGD) peptide sequence, the nanocomposite was deemed as a tumor-targeting, long-lived and oxygen-independent photosensitizer with promoted PDT efficiency for in vivo anti-tumor therapy. This oxygen-independent nanocomposite successfully overcame the hypoxia-related PDT resistance by water splitting, which opened a window to develop conventional semiconductors as photosensitizers for effective PDT.

中文翻译:

一种金属-半导体纳米复合材料,可用于光动力肿瘤治疗,是一种与氧无关的有效光敏剂

光动力疗法(PDT)被认为是最有前途的癌症治疗方法之一,为了促进PDT的发展,人们对氧依赖性光敏剂进行了深入研究。在这里,我们报道了一种由金属(Au沉积)和半导体(CdSe种子/ CdS纳米棒)作为光敏剂组成的高级混合纳米复合材料(HNC)。在可见光下,光生空穴被三维地限制在CdSe量子点中,离域电子被转移到Au尖端,这为水分解提供了氢和氧的放出部位,从而可以生成活性氧(ROS),而无需氧气参与。与没有沉积金属的半导体(在缺氧或缺氧的环境下,原始的CdSe种子/ CdS纳米棒(NRs))的HNC在体外均表现出显着增强的光触发ROS生成。在用Arg-Gly-Asp(RGD)肽序列修饰后,该纳米复合材料被认为是靶向肿瘤的,长寿命且不依赖氧的光敏剂,具有增强的PDT体内抗肿瘤治疗效率。这种不依赖氧的纳米复合材料通过水分解成功地克服了与缺氧相关的PDT耐受性,这为开发常规半导体作为有效PDT的光敏剂打开了一个窗口。
更新日期:2017-08-03
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