Although various noble metal and semiconducting molecules have been developed as photoacoustic (PA) agents, the use of semiconducting polymer-metal nanoparticle hybrid materials to enhance PA signal has not been explored. A novel semiconducting-plasmonic nanovesicle was fabricated by self-assembly of semiconducting poly(perylene diimide) (PPDI) and poly(ethylene glycol (PEG) tethered gold nanoparticles (Au@PPDI/PEG). A highly localized and strongly enhanced electromagnetic (EM) field is distributed between adjacent gold nanoparticles in the vesicular shell, where the absorbing collapsed PPDI is present. Significantly, the EM field in turn enhances the light absorption efficiency of PPDI, leading to a much greater photothermal effect and a stronger photoacoustic signal compared to PDI nanoparticle or gold nanovesicle alone. The optical property of the hybrid vesicle can be further tailored by controlling the ratio of PPDI and gold nanoparticle as well as the adjustable interparticle distance of gold nanoparticles localized in the vesicular shell. In vivo imaging and therapeutic evaluation demonstrated that the hybrid vesicle is an excellent probe for cancer theranostics.

中文翻译：

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具有增强的光学性能的半导体-等离子体金纳米颗粒的自组装，用于光声成像和光热疗法

尽管已开发出各种贵金属和半导体分子作为光声（PA）试剂，但尚未探索使用半导体聚合物-金属纳米颗粒杂化材料来增强PA信号。通过自组装的半导体聚（per二酰亚胺）（PPDI）和聚乙二醇（PEG）束缚金纳米粒子（Au @ PPDI / PEG）的自组装，制备了一种新型的半导体等离子体纳米囊泡。 ）场分布在小泡壳中相邻的金纳米粒子之间，其中存在吸收性塌陷的PPDI。值得注意的是，EM场反过来提高了PPDI的光吸收效率，与之相比，产生了更大的光热效应和更强的光声信号单独使用PDI纳米颗粒或金纳米囊泡。可以通过控制PPDI和金纳米颗粒的比例以及位于囊泡壳中的金纳米颗粒的可调节颗粒间距离，进一步调整杂化囊泡的光学特性。体内成像和治疗评估表明，混合囊泡是癌症治疗学的极佳探针。