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Interleukin-32α Inhibits Endothelial Inflammation, Vascular Smooth Muscle Cell Activation, and Atherosclerosis by Upregulating Timp3 and Reck through suppressing microRNA-205 Biogenesis
Theranostics ( IF 12.4 ) Pub Date : 2017-06-01 , DOI: 10.7150/thno.18407
Dong Ju Son , Yu Yeon Jung , Young Sik Seo , Heonyong Park , Dong Hun Lee , Sanghyeon Kim , Yoon-Seok Roh , Sang Bae Han , Do Young Yoon , Jin Tae Hong

Interleukin-32 (IL-32) is a multifaceted cytokine that promotes inflammation and regulates vascular endothelial cell behavior. Although some IL-32 isoforms have been reported to contribute to vascular inflammation and atherosclerosis, the functional role of IL-32α in vascular inflammation and atherogenesis has not been studied.

中文翻译:

白细胞介素32α通过抑制microRNA-205的生物发生,通过上调Timp3和Reck抑制内皮发炎,血管平滑肌细胞活化和动脉粥样硬化。

白介素32(IL-32)是一种多方面的细胞因子,可促进炎症并调节血管内皮细胞的行为。尽管已经报道了一些IL-32同工型有助于血管炎症和动脉粥样硬化,但是尚未研究IL-32α在血管炎症和动脉粥样硬化中的功能作用。
更新日期:2017-08-02
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