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Exploring the potential of natural and synthetic neuroprotective steroids against neurodegenerative disorders: A literature review
Medicinal Research Reviews ( IF 13.3 ) Pub Date : 2017-07-11 , DOI: 10.1002/med.21458
Ranju Bansal 1 , Ranjit Singh 1
Affiliation  

Neurodegeneration is a complex process, which leads to progressive brain damage due to loss of neurons. Despite exhaustive research, the cause of neuronal loss in various degenerative disorders is not entirely understood. Neuroprotective steroids constitute an important line of attack, which could play a major role against the common mechanisms associated with various neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Natural endogenous steroids induce the neuroprotection by protecting the nerve cells from neuronal injury through multiple mechanisms, therefore the structural modifications of the endogenous steroids could be helpful in the generation of new therapeutically useful neuroprotective agents. The review article will keep the readers apprised of the detailed description of natural as well as synthetic neuroprotective steroids from the medicinal chemistry point of view, which would be helpful in drug discovery efforts aimed toward neurodegenerative diseases.

中文翻译:

探索天然和合成的神经保护类固醇抗神经退行性疾病的潜力:文献综述

神经退行性变是一个复杂的过程,由于神经元的丧失而导致进行性脑损伤。尽管进行了详尽的研究,但尚未完全了解各种退行性疾病中神经元丢失的原因。神经保护性类固醇构成重要的攻击路线,可能对与各种神经退行性疾病(如阿尔茨海默氏病,帕金森氏病,亨廷顿氏病和肌萎缩性侧索硬化症)相关的常见机制起重要作用。天然内源性类固醇通过多种机制保护神经细胞免受神经元损伤,从而诱导神经保护作用,因此内源性类固醇的结构修饰可能有助于产生新的治疗上有用的神经保护剂。
更新日期:2017-07-11
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