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Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Philipp Linke, Natalie Munding, Esther Kimmle, Stefan Kaufmann, Kentaro Hayashi, Masaki Nakahata, Yoshinori Takashima, Masaki Sano, Martin Bastmeyer, Thomas Holstein, Sascha Dietrich, Carsten Müller‐Tidow, Akira Harada, Anthony D. Ho, Motomu Tanaka
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Amplified and Specific Staining of Protein Dimerization on Cell Membrane Catalyzed by Responsively Installed DNA Nanomachines for Cancer Diagnosis (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Zhenqiang Wang, Xiyue Xie, Kaifei Jin, Daqing Xia, Jing Zhu, Jixi Zhang
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Size‐dependent Blue Emission from Europium‐doped Strontium Fluoride Nanoscintillators for X‐Ray Activated Photodynamic Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Natasha Policei Marques, Mileni M. Isikawa, Zeinaf Muradova, Toby Morris, Ross Berbeco, Eder J. Guidelli
Successful implementation of X‐ray‐activated photodynamic therapy (X‐PDT) is challenging because most photosensitizers (PSs) absorb light in the blue region, but few nanoscintillators produce efficient blue scintillation. Here, we developed efficient blue‐emitting SrF2:Eu scintillating nanoparticles. Our optimized synthesis conditions resulted in cubic nanoparticles with 32 nm diameter and blue emission
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Ferrous/Ferric Ions Crosslinked Type II Collagen Multifunctional Hydrogel for Advanced Osteoarthritis Treatment (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Lili Wang, Xian Chen, Shenghong Wang, Jianrui Ma, Xiaxia Yang, Hongli Chen, Jianxi Xiao
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Metabolic Control During Macrophage Polarization by a Citrate‐Functionalized Scaffold for Maintaining Bone Homeostasis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Xiaopei Wu, Yuhao Xia, Honglian Dai, Chuhang Hong, Yanan Zhao, Wenying Wei, Dian Zheng
Metabolites, as markers of phenotype at the molecular level, can regulate the function of DNA, RNA, and proteins through chemical modifications or interactions with large molecules. Citrate is an important metabolite that affects macrophage polarization and osteoporotic bone function. Therefore, a better understanding of the precise effect of citrate on macrophage polarization may provide an effective
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Molecularly Imprinted Macroporous Hydrogel Promotes Bone Regeneration via Osteogenic Induction and Osteoclastic Inhibition Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Jingxiao Chen, Yihan Jing, Yanhong Liu, Yongxi Luo, Yutong He, Xiaozhong Qiu, Qingbin Zhang, Huiyong Xu
Macroporous hydrogels offer physical supportive spaces and bio‐instructive environment for the seeded cells, where cell‐scaffold interactions directly influence cell fates and subsequently affect tissue regeneration post‐implantation. Effectively modifying bioactive motifs at the inner pore surface provides appropriate niches for cell‐scaffold interactions. A molecular imprinting method and sacrificial
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A Novel Conductive Polypyrrole‐Chitosan Hydrogel Containing Human Endometrial Mesenchymal Stem Cell‐Derived Exosomes Facilitated Sustained Release for Cardiac Repair (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Changping Yan, Xinzhu Wang, Qi Wang, Haiyan Li, Huifang Song, Jingli Zhou, Zexu Peng, Wenjuan Yin, Xuemei Fan, Kun Yang, Bingrui Zhou, Yuxiang Liang, Zengyu Jiang, Yuwei Shi, Sanyuan Zhang, Sheng He, Ren‐Ke Li, Jun Xie
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Material‐Intrinsic NIR‐Fluorescence Enables Image‐Guided Surgery for Ceramic Fracture Removal (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Robert Nißler, Elena Totter, Sebastian G. Walter, Justus T. Metternich, Oscar Cipolato, Dimitri Nowack, Alexander Gogos, Inge K. Herrmann
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Novel‐Ink‐Based Direct Ink Writing of Ti6Al4V Scaffolds with Sub‐300 µm Structural Pores for Superior Cell Proliferation and Differentiation (Adv. Healthcare Mater. 10/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-17 Chao Xu, Yan Xu, Hao Chen, Qing Han, Wenzheng Wu, Lu Zhang, Qingping Liu, Jincheng Wang, Luquan Ren
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Unique Advantages of Dendrimers‐Structured Mesoporous Silica Nanoparticles over Traditional Hollow ones in Delivering Bcl2‐Functional Converting Peptide for Multidrug Resistant Cancer Treatment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Yuehuang Wu, Fangmei Ma, Lixue Yu, Ruimiao Lin, Sijin Lin, Zhihan Guo, Min Zhou, Mingyu Li, Yi Zhang, Jingjing Xie
Innovative silica nanomaterials have made the significant advancements in curative therapy against cancers with multidrug resistance (MDR). The study on different‐nanostructured mesoporous silica nanoparticles (MSNs) with discrepant pore sizes affecting biomacromolecules in resisting cancer MDR hasn't been reported yet. In this study, a systematic comparison of 6 nm‐pore sized hollow‐structured MSNs
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Modelling Structural Elements and Functional Responses to Lymphatic‐Delivered Cues in a Murine Lymph Node on a Chip Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Corrado Mazzaglia, Hafsa Munir, Iek M. Le, Magda Gerigk, Yan Yan Shery Huang, Jacqueline D. Shields
Lymph nodes (LNs) are organs of the immune system, critical for maintenance of homeostasis and initiation of immune responses, yet there are few models that accurately recapitulate LN functions in vitro. To tackle this issue, an engineered murine LN (eLN) was developed, replicating key cellular components of the mouse LN; incorporating primary murine lymphocytes, fibroblastic reticular cells (FRCs)
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Biofabrication Directions in Recapitulating the Immune System‐on‐a‐Chip Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Robine Janssen, Laura Benito‐Zarza, Pim Cleijpool, Marta G Valverde, Silvia M Mihăilă, Shanna Bastiaan‐Net, Johan Garssen, Linette E.M. Willemsen, Rosalinde Masereeuw
Ever since the implementation of microfluidics in the biomedical field, in vitro models have experienced unprecedented progress that has led to a new generation of highly complex miniaturized cell culture platforms, known as Organs‐on‐a‐Chip (OoC). These devices aim to emulate biologically relevant environments, encompassing perfusion and other mechanical and/or biochemical stimuli, to recapitulate
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Cuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-16 Jiacheng Lu, Yuqing Miao, Yuhao Li
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Pyridine‐2,6‐dicarboxamide proligands and their Cu(II)/Zn(II) complexes Targeting Staphylococcus Aureus for the Attenuation of In‐vivo Dental Biofilm Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-15 Kajal Chaudhary, Bhumika Agrahari, Bhumika Biswas, Niranjan Chatterjee, Ayushi Chaudhary, Ashwini Kumar, Himanshu Sonkar, Sayari Dewan, Deepanshi Saxena, Abdul Akhir, Nidhi Malhotra, Sidharth Chopra, Santosh Misra, Saravanan Matheswaran, Ritika Gautam Singh
In the pursuit to combat stubborn bacterial infections, particularly those stemming from gram‐positive bacteria, our study is an attempt to craft a precision‐driven platform characterized by unparalleled selectivity, specificity, and synergistic antimicrobial mechanisms. Leveraging remarkable potential of metalloantibiotics in antimicrobial applications, herein, we rationally design, synthesize, and
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Triplet‐Triplet Annihilation Upconversion Based Photolysis: Applications in Photopharmacology Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-13 Maxime Klimezak, Juliane Chaud, Anaïs Brion, Frédéric Bolze, Benoit Frisch, Béatrice Heurtault, Antoine Kichler, Alexandre Specht
The emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off‐target toxicity outside the disease location of many drugs for the treatment of a given pathology. The use of photolytic reactions looks very attractive for a light activated drug release but requires to develop photolytic reactions sensitive
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Fabrication and Characterization of PDMS Waveguides for Flexible Optrodes Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Linda Rudmann, Daniel Scholz, Marie T. Alt, Alexander Dieter, Eva Fiedler, Tobias Moser, Thomas Stieglitz
With the growth of optogenetic research, the demand for optical probes tailored to specific applications is ever rising. Specifically, for applications like the coiled cochlea of the inner ear, where planar, stiff and non‐conformable probes can hardly be used, transitioning from commonly used stiff glass fibers to flexible probes is required, especially for long‐term use. Following this demand, Polydimethylsiloxane
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Heterojunction‐mediated Co‐adjustment of Band Structure and Valence State for Achieving Selective Regulation of Semiconductor Nanozymes Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Jiahao Huang, Xiaodan Jia, Yue Wang, Yue Qiao, Xiue Jiang
Improving reaction selectivity is the next target for nanozymes to mimic natural enzymes. Currently, the majority of strategies in this field are exclusively applicable to metal‐organic‐based or organic‐based nanozymes, while limited in regulating metal oxide‐based semiconductor nanozymes. Herein, taking semiconductor Co3O4 as an example, we propose a heterojunction strategy to precisely regulate nanozyme
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Nanofiber Peptides for Bacterial Trapping: A Novel Approach to Antibiotic Alternatives in Wound Infections Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Hao Yang, Jiufeng Wang, Xue Wang, Siyu Wang, Jieru Xu, Qiang Shan, Jingyi Wang, Xi Ma, Yaohong Zhu
The pervasive employment of antibiotics has engendered the advent of drug‐resistant bacteria, imperiling the well‐being and health of both humans and animals. Infections precipitated by such multi‐resistant bacteria, especially those induced by methicillin‐resistant Staphylococcus aureus, pervade hospital settings, constituting a grave menace to patient vitality. Antimicrobial peptides have garnered
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Hybrid Bioactive Hydrogel Promotes Liver Regeneration Through the Activation of Kupffer Cells and ECM Remodeling After Partial Hepatectomy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Yixiao Pan, Zhigang Zheng, Xueliang Zhang, Shupeng Liu, Shiya Zhuansun, Shiming Gong, Shilun Li, Hongye Wang, Yiwen Chen, Taihua Yang, Huimin Wu, Feng Xue, Qiang Xia, Kang He
Partial hepatectomy is an essential surgical technique used to treat advanced liver diseases such as liver tumors, as well as for performing liver transplants from living donors.However, postoperative complications such as bleeding, abdominal adhesions, wound infections, and accelerated liver regeneration pose significant challenges and increase morbidity and mortality rates.We have developed a self‐repairing
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The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels – A Stable Process? Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-12 Michael Bartolf‐Kopp, Tomasz Jungst
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Immunomodulation Using BMP-7 and IL-10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma-Like Environment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Matthias Guido Wiesli, Matthias Werner Huber, Bernhard Weisse, Robert Zboray, Stefanie Kiderlen, Arlyng González-Vázquez, Katharina Maniura-Weber, Markus Rottmar, William Arthur Lackington
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An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo-Sensitizer Evokes Mutually Reinforcing "Closed-Loop" Ferroptosis and Immunotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Qingyan Ren, Haobing Wang, Dan Li, Anyi Dao, Jiajun Luo, Deliang Wang, Pingyu Zhang, Huaiyi Huang
The hypoxic microenvironment of solid tumors severely lowers the efficacy of oxygen-dependent photodynamic therapy (PDT). The development of hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re-TTPY) to develop a “closed-loop” therapy based on PDT-induced ferroptosis and immune therapy is reported. Due to its electron donor–acceptor (D–A) structure
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Graphene Quantum Dots Eradicate Resistant and Metastatic Cancer Cells by Enhanced Interfacial Inhibition Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Yan Su, Kai Ye, Jinyan Hu, Zhenlin Zhang, Yang Wang, Bijiang Geng, Dengyu Pan, Longxiang Shen
Drug‐resistant and metastatic cancer cells such as a small population of cancer stem cells (CSCs) play a crucial role in metastasis and relapse. Conventional small‐molecule chemotherapeutics, however, are unable to eradicate drug‐resistant CSCs owing to limited interface inhibitory effects, leading to chemotherapy failure. Herein, we report that enhanced interfacial inhibition leading to eradication
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Spatiotemporal Concurrent PARP Inhibitor Sensitization based on Radiation‐Responsive Nanovesicles for Lung Cancer Chemoradiotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Fei Kang, Meng Niu, Zijian Zhou, Mingru Zhang, Hehe Xiong, Fantian Zeng, Jing Wang, Xiaoyuan Chen
The implementation of chemoradiation combinations has gained great momentum in clinical practices. However, the full utility of this paradigm is often restricted by the discordant tempos of action of chemotherapy and radiotherapy. Here, we developed a gold nanoparticle‐based radiation‐responsive nanovesicle system loaded with cisplatin and veliparib, denoted as CV‐Au NVs, to augment the concurrent
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Engineering Microorganisms for Cancer Immunotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-10 Dingkang Liu, Lichao Yu, Haibo Rong, Lubin Liu, Jun Yin
Cancer immunotherapy presents a promising approach to fight against cancer by utilizing the immune system. Recently, engineered microorganisms have emerged as a potential strategy in cancer immunotherapy. These microorganisms, including bacteria and viruses, can be designed and modified using synthetic biology and genetic engineering techniques to target cancer cells and modulate the immune system
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Stiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient Hydrogels Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Yong Hwee Tan, Kimberley C. W. Wang, Ian L. Chin, Rowan W. Sanderson, Jiayue Li, Brendan F. Kennedy, Peter B. Noble, Yu Suk Choi
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Engineering Wet‐resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Mahshid Shokri, Mahshid Kharaziha, Hossein Ahmadi Tafti, Faezeh Dalili, Rouhollah Mehdinavaz Aghdam, Mohamadreza Baghaban Eslaminejad
Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. We have created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc
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High‐density, Conformable Conducting Polymer‐Based Implantable Neural Probes for the Developing Brain Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Liang Ma, Duncan J. Wisniewski, Claudia Cea, Dion Khodagholy, Jennifer N. Gelinas
Neurologic and neuropsychiatric disorders substantially impact the pediatric population, but there is a lack of dedicated devices for monitoring the developing brain in animal models, leading to gaps in mechanistic understanding of how brain functions emerge and their disruption in disease states. Due to the small size, fragility, and high‐water content of immature neural tissue, as well as the absence
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A Mesoporous Silica‐loaded Multi‐functional Hydrogel Enhanced Tendon Healing via Immunomodulatory and pro‐regenerative Effects Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-09 Renwen Wan, Zhiwen Luo, Xiaoshuang Nie, Xinting Feng, Yanwei He, Fangqi Li, Shan Liu, Wenbo Chen, Beijie Qi, Haocheng Qin, Wei Luo, Hanli Zhang, Hongyi Jiang, Junming Sun, Xuanyong Liu, Qing Wang, Xiliang Shang, Jiajun Qiu, Shiyi Chen
Tendon injuries are pervasive orthopedic injuries encountered by the general population. Nonetheless, recovery after severe injuries such as Achilles tendon injury is limited. Consequently, there is a pressing need to devise interventions, including biomaterials, that foster tendon healing. Regrettably, tissue engineering treatments have faced obstacles in crafting appropriate tissue scaffolds and
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Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Beichen Zhang, Wanshun Wang, Peng Gao, Xiang Li, Lingling Chen, Zefeng Lin, Hu Chen, Wenhao Liang, Zhiyuan Kong, Dingkun Lin, Xiaona Wu, Tao Zhang
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Homo‐dyad with outer hydration layer approach for developing NIR‐II chromophore of high stability and water‐solubility as injectable and sprayable optical probe Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Zunpan She, Rong Li, Fang Zeng, Shuizhu Wu
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A Novel Coacervate Embolic Agent for Tumor Chemoembolization Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Menghui Liu, Yang Sun, Yitong Zhou, Yanlv Chen, Meng Yu, Liujun Li, Leye Yan, Yajun Yuan, Jiayao Chen, Kaixiang Zhou, Hong Shan, Xin Peng
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Tunable In Situ Synthesis of Ultra‐Thin Extracellular Matrix‐Derived Membranes in Organ‐on‐a‐Chip Devices Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Jeremy D. Newton, Yuetong Song, Siwan Park, Kayshani R. Kanagarajah, Amy P. Wong, Edmond W. K. Young
Thin cell culture membranes in organ‐on‐a‐chip (OOC) devices are used to model a wide range of thin tissues. While early and most current platforms use micro‐porous or fibrous elastomeric or thermoplastic membranes, there is an emerging class of devices using extra‐cellular matrix (ECM) protein‐based membranes to improve their biological relevance. These ECM‐based membranes present physiologically
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pH-Triggered Transformable Peptide Nanocarriers Extend Drug Retention for Breast Cancer Combination Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-08 Xiaomeng Yuan, Xiaoying Liu, Hongjie Li, Shan Peng, Haiqin Huang, Zhe Yu, Limei Chen, Xinlu Liu, Jingkun Bai
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Polymer Backpack‐loaded Tissue Infiltrating Monocytes for Treating Cancer Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-06 Neha Kapate, Michael Dunne, Alexander P. Gottlieb, Malini Mukherji, Vineeth Chandran Suja, Supriya Prakash, Kyung Soo Park, Ninad Kumbhojkar, Jennifer L. Guerriero, Samir Mitragotri
Adoptive cell therapies are dramatically altering the treatment landscape of cancer. However, treatment of solid tumors remains a major unmet need, in part due to limited adoptive cell infiltration into the tumor and in part due to the immunosuppressive tumor microenvironment. The heterogeneity of tumors and presence of non‐responders also calls for development of antigen‐independent therapeutic approaches
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Cell Membrane‐Camouflaged Chitosan‐Polypyrrole Nanogels Co‐Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-06 Qiuyu Yu, Yue Gao, Waicong Dai, Danni Li, Lu Zhang, Meera Moydeen Abdul Hameed, Rui Guo, Min Liu, Xiangyang Shi, Xueyan Cao
The development of functional nanoplatforms to improve the chemotherapy outcome and inhibit distal cancer cell metastasis remains an extreme challenge in cancer management. In this work, we report a human‐derived PC‐3 cancer cell membrane‐camouflaged chitosan‐polypyrrole nanogel (CH‐PPy NG) platform, which can be loaded with chemotherapeutic drug docetaxel (DTX) and RANK siRNA for targeted chemotherapy
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Quantitative Biofabrication Platform for Collagen‐Based Peripheral Nerve Grafts with Structural and Chemical Guidance (Adv. Healthcare Mater. 9/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-05 Heran Wang, Yiming Hao, Kai Guo, Lianqing Liu, Bing Xia, Xue Gao, Xiongfei Zheng, Jinghui Huang
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Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro (Adv. Healthcare Mater. 9/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-05 Abinaya Sindu Pugazhendhi, Anouska Seal, Megan Hughes, Udit Kumar, Elayaraja Kolanthai, Fei Wei, Jonathan D. Schwartzman, Melanie J. Coathup
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Enhanced Electrochemical Characterization of the Immune Checkpoint Protein PD‐L1 using Aptamer‐Functionalized Magnetic Metal‐Organic Frameworks (Adv. Healthcare Mater. 9/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-05 Ying Ma, Maoqiang Wu, Fayin Mo, Zuanguang Chen, Jing Lu, Duanping Sun
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Local Spinal Cord Injury Treatment Using a Dental Pulp Stem Cell Encapsulated H2S Releasing Multifunctional Injectable Hydrogel (Adv. Healthcare Mater. 9/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-05 Abdullkhaleg Ali Albashari, Yan He, Yu Luo, Xingxiang Duan, Jihea Ali, Mingchang Li, Dehao Fu, Yangfan Xiang, Youjian Peng, Song Li, Lihua Luo, Xingjie Zan, Tushar Kumeria, Qingsong Ye
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Covalent Coupling Assisted Hydrophilic Perovskite Spheres for Ratiometric Fluorescent Visual Multichannel Immunoassay (Adv. Healthcare Mater. 9/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-05 Yaqin Han, Jia An, Mengdi Yuan, Junan Fang, Jiajing Zhang, Lanju Liang, Yufei Liu
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High‐Resolution Additive Manufacturing of a Biodegradable Elastomer with A Low‐Cost LCD 3D Printer (Adv. Healthcare Mater. 9/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-05 Vahid Karamzadeh, Molly L. Shen, Hossein Ravanbakhsh, Ahmad Sohrabi‐Kashani, Sargol Okhovatian, Houman Savoji, Milica Radisic, David Juncker
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A Manganese-Based Nanodriver Coordinates Tumor Prevention and Suppression through STING Activation in Glioblastoma Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Wenyuan Zhang, Liejing Lu, Zheng Zhu, Fuan Deng, Wenchang Zhang, Fengyi Wang, Ping Zeng, Haonan Shi, Tong Wang, Yichi Chen, Yue Song, Yiping Liu, Tianze Kang, Kai Li, Jie Mao, Zhengwei Liu, Lu Zhang
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Investigation of the Dysfunction Caused by High Glucose, Advanced Glycation End Products, and Interleukin-1 Beta and the Effects of Therapeutic Agents on the Microphysiological Artery Model Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Ungsig Nam, Jaesang Kim, Hee-gyeong Yi, Jessie S. Jeon
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Synergistic Antimicrobial Glycyrrhizic Acid‐based Functional Biosensing composite for Sensitive Glucose Monitoring and Collaborative Wound Healing Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Xiao Wang, Haoling Huo, Yanming Zhong, Yingfei Yang, Huaijun Lin, Lin Cao, Qiwei Wang, Congjie Xu, Zhidan Lin, Wei Li, Peng Zhang
High glucose blood and bacterial infection remain major issues for the slow healing of diabetic wounds, so developing functional biosensing composite with excellent antibacterial and remarkable glucose response sensitivity is necessary and prospective. Herein, by in situ synthesis AgNPs on the surface of self‐prepared PTIGA elastomers, PTIGA‐AgNPs conductive composites were obtained with efficient
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Engineering Nanozymes for Tumor Therapy via Ferroptosis Self-Amplification Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Shuyu Liu, Yi Wei, Yuan Liang, Pengye Du, Pengpeng Lei, Duo Yu, Hongjie Zhang
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Zwitterionic Strategy to Stabilize Self-Immolative Polymer Nanoarchitecture under Physiological pH for Drug Delivery In Vitro and In Vivo Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Shahidkhan Pathan, Manickam Jayakannan
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Recent Trends of Bioanalytical Sensors with Smart Health Monitoring Systems: From Materials to Applications Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Thi Sinh Vo, Trung Hoang, Tran Thi Bich Chau Vo, Byounghyun Jeon, Vu Hoang Nguyen, Kyunghoon Kim
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Making the Brightest Ones Dim: Maximizing the Photothermal Conversion Efficiency of BODIPY-Based Photothermal Agents Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-04 Gibeom Kim, Yongyang Luo, Myunghwan Shin, Jean Bouffard, Jeehyeon Bae, Youngmi Kim
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Development of an Injectable Biphasic Hyaluronic Acid-Based Hydrogel With Stress Relaxation Properties for Cartilage Regeneration Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-03 Han-Sem Kim, Cheng Ji Li, Sung-Min Park, Kyung Wook Kim, Ji-Hun Mo, Guang-Zhen Jin, Hae-Hyoung Lee, Hae-Won Kim, Ueon Sang Shin, Jung-Hwan Lee
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Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-03 Yu Tian, Fei Jiang, Haijiao Xie, Zhe Chi, Chenguang Liu
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A TLR4-Targeting Bioactive Peptide Hydrogel to Regulate Immune-Microenvironment for Diabetic Wound Repair Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-03 Chuanjiang Jian, Minjia Wang, Yunyun Qian, Xuejiao Song, Li Wang, Ling Li, Lulu Huang, Guan Wang, Xianjie Shi, Jinqiao Dong, Hao Li, Ang Lin, Leilei Shi
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Biocompatible Electronic Skins for Cardiovascular Health Monitoring Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-03 Yucong Du, Ji Hong Kim, Hui Kong, Anne Ailina Li, Ming Liang Jin, Do Hwan Kim, Yin Wang
Cardiovascular diseases represent a significant threat to the overall well‐being of the global population. Continuous monitoring of vital signs related to cardiovascular health is essential for improving daily health management. Currently, there has been remarkable proliferation of technology focused on collecting data related to cardiovascular diseases through daily electronic skin monitoring. However
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Antibody-Conjugated Nanogel with Two Immune Checkpoint Inhibitors for Enhanced Cancer Immunotherapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-03 Yun Jin Chae, Kang-Gon Lee, Doogie Oh, Su-Kyoung Lee, Yongdoo Park, Jongseong Kim
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Precisely Self‐Cooperative Nanoassembly Enables Photothermal/Ferroptosis Synergistic Tumor Eradication Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-03 Xiaohong Yang, Chengcheng Feng, Pengfei Wang, Shishi Xie, Yuequan Wang, Haotian Zhang, Zhonggui He, Shenwu Zhang, Cong Luo
Ferroptosis has been identified as a potential target for anticancer therapy. However, most conventional ferroptosis inducers not only fail to trigger intracellular lipid peroxidation storm but are also prone to cause ferroptosis‐related toxicity through off‐target destruction of intracellular antioxidant defense systems. Therefore, a potent and highly tumor‐specific ferroptosis induction modality
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A Gelatin/Alginate Double Network Hydrogel Nerve Guidance Conduit Fabricated by a Chemical-Free Gamma Radiation for Peripheral Nerve Regeneration Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-02 Junghyun Kim, Junggeon Park, Goeun Choe, Sung-In Jeong, Hyung-Seok Kim, Jae Young Lee
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Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-02 Yuying Liu, Zeyu Jiang, Xiao Yang, Yin Wang, Bin Yang, Qinrui Fu
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Exploring Mechanisms of Lipid Nanoparticle-Mucus Interactions in Healthy and Cystic Fibrosis Conditions Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-04-02 Belal Tafech, Mohammad-Reza Rokhforouz, Jerry Leung, Molly MH Sung, Paulo JC Lin, Don D Sin, Daniel Lauster, Stephan Block, Bradley S. Quon, Ying Tam, Pieter Cullis, James J Feng, Sarah Hedtrich