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Mechanisms and Medicines for Remyelination
Annual Review of Medicine ( IF 10.5 ) Pub Date : 2017-01-18 00:00:00 , DOI: 10.1146/annurev-med-050715-104400
Mark Bothwell 1
Affiliation  

Demyelination of central nervous system axons, associated with traumatic injury and demyelinating diseases such as multiple sclerosis, causes impaired neural transmission and ultimately axon degeneration. Consequently, extensive research has focused on signaling systems that promote myelinating activity of oligodendrocytes or promote production of new oligodendrocytes from oligodendrocyte progenitor cells. Many receptor systems, notably including growth factor receptors and G protein–coupled receptors, control myelination. A number of recent clinical trials target these receptor signaling pathways.

中文翻译:


髓鞘再生的机制和药物

与创伤性损伤和诸如多发性硬化症之类的脱髓鞘疾病相关的中枢神经系统轴突脱髓鞘引起神经传递受损,并最终导致轴突变性。因此,广泛的研究集中于促进少突胶质细胞的髓鞘形成活性或促进由少突胶质细胞祖细胞产生新的少突胶质细胞的信号系统。许多受体系统控制髓鞘形成,特别是包括生长因子受体和G蛋白偶联受体。许多最近的临床试验针对这些受体信号传导途径。

更新日期:2017-01-18
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