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Tissue Engineering: Toward a New Era of Medicine
Annual Review of Medicine ( IF 10.5 ) Pub Date : 2017-01-18 00:00:00 , DOI: 10.1146/annurev-med-102715-092331
Ashkan Shafiee 1 , Anthony Atala 1
Affiliation  

The goal of tissue engineering is to mitigate the critical shortage of donor organs via in vitro fabrication of functional biological structures. Tissue engineering is one of the most prominent examples of interdisciplinary fields, where scientists with different backgrounds work together to boost the quality of life by addressing critical health issues. Many different fields, such as developmental and molecular biology, as well as technologies, such as micro- and nanotechnologies and additive manufacturing, have been integral for advancing the field of tissue engineering. Over the past 20 years, spectacular advancements have been achieved to harness nature's ability to cure diseased tissues and organs. Patients have received laboratory-grown tissues and organs made out of their own cells, thus eliminating the risk of rejection. However, challenges remain when addressing more complex solid organs such as the heart, liver, and kidney. Herein, we review recent accomplishments as well as challenges that must be addressed in the field of tissue engineering and provide a perspective regarding strategies in further development.

中文翻译:


组织工程:迈向医学的新纪元

组织工程的目的是通过功能性生物结构的体外制造来减轻供体器官的严重短缺。组织工程学是跨学科领域最突出的例子之一,具有不同背景的科学家通过解决关键的健康问题,共同致力于提高生活质量。许多不同的领域,例如发育和分子生物学,以及技术,例如微技术和纳米技术以及增材制造,已经成为推进组织工程领域不可或缺的一部分。在过去的20年中,利用自然界治愈患病的组织和器官的能力已取得了令人瞩目的进步。患者已经接受了由自己的细胞制成的实验室生长的组织和器官,从而消除了排斥的风险。然而,处理更复杂的实体器官(例如心脏,肝脏和肾脏)时,挑战仍然存在。本文中,我们回顾了组织工程领域中的最新成就以及必须解决的挑战,并提供了有关进一步开发策略的观点。

更新日期:2017-01-18
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