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Regulation of mRNA Decay in Bacteria
Annual Review of Microbiology ( IF 10.5 ) Pub Date : 2016-09-08 00:00:00 , DOI: 10.1146/annurev-micro-091014-104515
Bijoy K. Mohanty 1 , Sidney R. Kushner 1
Affiliation  

Gram-negative and gram-positive bacteria use a variety of enzymatic pathways to degrade mRNAs. Although several recent reviews have outlined these pathways, much less attention has been paid to the regulation of mRNA decay. The functional half-life of a particular mRNA, which affects how much protein is synthesized from it, is determined by a combination of multiple factors. These include, but are not necessarily limited to, (a) stability elements at either the 5′ or the 3′ terminus, (b) posttranscriptional modifications, (c) ribosome density on individual mRNAs, (d) small regulatory RNA (sRNA) interactions with mRNAs, (e) regulatory proteins that alter ribonuclease binding affinities, (f) the presence or absence of endonucleolytic cleavage sites, (g) control of intracellular ribonuclease levels, and (h) physical location within the cell. Changes in physiological conditions associated with environmental alterations can significantly alter the impact of these factors in the decay of a particular mRNA.

中文翻译:

细菌中mRNA衰变的调控

革兰氏阴性和革兰氏阳性细菌使用多种酶促途径降解mRNA。尽管最近的一些综述概述了这些途径,但是对mRNA衰变的调节的关注却很少。特定mRNA的功能半衰期会影响多种蛋白质的合成,该半衰期是由多种因素共同决定的。这些包括但不限于(a)5'或3'末端的稳定性元件,(b)转录后修饰,(c)单个mRNA上的核糖体密度,(d)小调节RNA(sRNA)与mRNA相互作用,(e)改变核糖核酸酶结合亲和力的调节蛋白,(f)是否存在核酸内切酶裂解位点,(g)控制细胞内核糖核酸酶水平,以及(h)细胞内的物理位置。与环境变化相关的生理条件的变化可以显着改变这些因素对特定mRNA衰变的影响。
更新日期:2017-06-21
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